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首页> 外文期刊>Ophthalmic plastic and reconstructive surgery >Periocular inflammation after retrobulbar chlorpromazine (thorazine) injection.
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Periocular inflammation after retrobulbar chlorpromazine (thorazine) injection.

机译：球后注射氯丙嗪（噻嗪）后眼周炎。

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PURPOSE: Retrobulbar chlorpromazine injection is a relatively recently described method of pain control in nonseeing eyes. This report illustrates severe sterile inflammation as a potential complication. METHODS: In this university-based, retrospective, small case series, we reviewed the records of 2 female patients and 1 male patient (ages, 13 to 89 years) who developed severe inflammation after retrobulbar chlorpromazine injection. RESULTS: Three patients had development of severe periocular edema after retrobulbar chlorpromazine injection. Two had development of chemosis, limited extraocular motility, proptosis, and incomplete eyelid closure, necessitating temporary tarsorrhaphy. The third patient had development of facial edema involving the ipsilateral eyelids, forehead, and cheek. Strikingly, it extended to the contralateral face. All 3 patients denied discomfort. In each case, swelling was first noted the day after injection and progressed for 1 week. All were treated with topical lubrication and two with temporary tarsorrhaphy. Resolution occurred within 3 weeks in each case. CONCLUSIONS: Severe periocular inflammation can result from retrobulbar chlorpromazine injection and may manifest as chemosis, proptosis, limited ocular motility, and facial swelling that may extend well beyond the eyelids. Awareness of this potential adverse reaction is important both for patient counseling before injection and subsequent treatment. Specifically, a sterile inflammatory response should be differentiated from infection to avoid inappropriate therapy.
机译：目的：球后氯丙嗪注射液是一种较新近描述的无视眼疼痛控制方法。该报告说明严重的无菌炎症是潜在的并发症。方法：在这个以大学为基础的回顾性小病例系列研究中，我们回顾了2例女性患者和1例男性患者（年龄13至89岁）的记录，这些患者在注射球后注射氯丙嗪后出现严重炎症。结果：3例球后注射氯丙嗪后出现严重的眼周水肿。两人发生了化学反应，眼外运动受限，眼球突出和眼睑闭合不完全，因此需要临时睑环出血。第三例患者出现了同侧眼睑，额头和脸颊的面部水肿。令人惊讶的是，它延伸到了对侧脸。所有3名患者否认不适。在每种情况下，注射后第二天首先注意到肿胀，并持续1周。所有患者均接受局部润滑治疗，其中两名患者患有临时性睑癣。在每种情况下，解决方案均在3周内发生。结论：球后注射氯丙嗪可导致严重的眼周炎症，并可能表现为化学反应，眼球突出，眼部运动受限和面部肿胀，可能会延伸至眼睑以外。意识到这种潜在的不良反应对于注射前的患者咨询以及后续治疗都非常重要。具体而言，应将无菌性炎症反应与感染区分开，以避免不适当的治疗。

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