The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.

Wiens M; Bausen M; Natalio F; Link T; Schlossmacher U; Muller WE

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The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.

机译：硅酸盐素-α相互作用物silintaphin-1在仿生生物矿化中的作用。

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Biosilicification in sponges is initiated by formation of proteinaceous filaments, predominantly consisting of silicateins. Silicateins enzymatically catalyze condensation of silica nanospheres, resulting in symmetric skeletal elements (spicules). In order to create tailored biosilica structures in biomimetic approaches it is mandatory to elucidate proteins that are fundamental for the assembly of filaments. Silintaphin-1 is a core component of modularized filaments and also part of a spicule-enfolding layer. It bears no resemblance to other proteins, except for the presence of an interaction domain that is fundamental for its function as scaffold/template. In the presence of silicatein silintaphin-1 facilitates the formation of in vitro filaments. Also, it directs the assembly of gamma-Fe(2)O(3) nanoparticles and surface-immobilized silicatein to rod-like biocomposites, synthetic spicules. Thus, silintaphin-1 will contribute to biomimetic approaches that pursue a controlled formation of patterned biosilica-based materials. Its combination with gamma-Fe(2)O(3) nanoparticles and immobilized silicatein will furthermore inspire future biomedical applications and clinical diagnostics.

机译：海绵中的生物硅化作用是通过形成蛋白质丝（主要由硅酸盐）组成而引发的。硅酸盐素以酶促方式催化二氧化硅纳米球的缩合，产生对称的骨架元素（刺）。为了在仿生方法中创建量身定制的生物二氧化硅结构，必须阐明对长丝组装至关重要的蛋白质。 Silintaphin-1是模块化长丝的核心组件，也是针刺包层的一部分。它与其他蛋白质没有任何相似之处，只是存在相互作用结构域，而该相互作用域对其支架/模板的功能至关重要。在存在硅酸盐的情况下，silintaphin-1有助于体外丝的形成。此外，它指导组装的γ-Fe（2）O（3）纳米粒子和表面固定的硅酸盐到棒状生物复合材料，合成针头。因此，silintaphin-1将有助于仿生方法，以控制图案化生物硅基材料的形成。它与γ-Fe（2）O（3）纳米颗粒和固定的硅酸盐的结合将进一步激发未来的生物医学应用和临床诊断。

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《Biomaterials》 |2009年第8期|共9页
作者
Wiens M; Bausen M; Natalio F; Link T; Schlossmacher U; Muller WE;
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正文语种 eng
中图分类医用一般科学;
关键词
Silicates; Iron measurement; Role; Proteins; 硅酸盐类; 角色; 蛋白质类;

机译：Silicates;Iron measurement;Role;Proteins;硅酸盐类;角色;蛋白质类;

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机译：硅酸盐素-α相互作用物silintaphin-1在仿生生物矿化中的作用。
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The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.

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