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首页> 外文期刊>Ophthalmology >Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.
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Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.

机译：使用纵向共聚焦扫描激光断层扫描技术检测区域和容积盘参数的变化。

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PURPOSE: To develop a clinically specific strategy for optic nerve head (ONH) surface change detection within longitudinally acquired confocal scanning laser tomographic (CSLT) images. DESIGN: Experimental study. PARTICIPANTS AND/OR CONTROLS: Twelve monkeys, each with one glaucomatous and one contralateral normal eye. MAIN OUTCOME MEASURES: Detection of ONH surface change within the CSLT images of each monkey's glaucomatous eye. METHODS: Six 10 and six 15 CSLT images and four stereo optic disc photographs were obtained from both eyes of 12 monkeys on 3 separate days (imaging sessions) and then every 2 weeks after laser to one eye (study eye) to elevate intraocular pressure. For each set of 10 and 15 images per eye (and for each of the 7-25 imaging sessions per monkey), 37 CSLT parameters were calculated. Univariate change required an individual parameter to change in excess of its analysis of variance-determined minimum detectable change (MDC) value. Multivariate change required groups of three parameters, considered together, to demonstrate significant change as determined by a multivariate analysis of variance. The rate of false-positive change detection for each individual parameter and for a group of three-parameter combinations was determined using both a one-in-a-row strategy (change at a single session) and a two-in-a-row strategy (change at two successive sessions) within the postlaser images of the 12 unchanging contralateral normal eyes. Change detection within the study eye images was then assessed for only those individual parameters and three-parameter combinations that were clinically specific (i.e., showed less than 10% false-positive change detection in the normal eyes). RESULTS: A total of 36 prelaser (three per monkey) imaging sessions and 158 postlaser (4-22/monkey) imaging sessions was performed. Clinically specific change detection (low rate of false positives) was achieved only with the two-in-a-row strategy. Overall, multivariate ONH surface change detection performed best; the best-performing three-parameter combination detected only 8 change events (4 onset and 4 progression) in 139 imaging sessions within the postlaser imaging sessions of the contralateral normal eyes and a total of 47 change events (11 onset and 36 progression) within the postlaser imaging sessions of the 12 study eyes. Counterintuitive (anterior) change occurred in most parameters within the late postlaser imaging sessions of the study eyes followed to end-stage damage. CONCLUSIONS: Clinically specific detection of the onset and progression of glaucomatous ONH surface change is possible within longitudinally acquired CSLT images.
机译：目的：在纵向采集的共聚焦扫描激光断层扫描（CSLT）图像内开发用于视神经乳头（ONH）表面变化检测的临床特定策略。设计：实验研究。参与者和/或控制：十二只猴子，每只猴子有一只青光眼和一只对侧正常眼。主要观察指标：检测每只猴子的青光眼的CSLT图像中的ONH表面变化。方法：在12天的猴子中，分别在3天（成像阶段）和随后每两周激光照射到一只眼睛（研究眼睛）以提高眼内压的过程中，从12只猴子的两只眼睛获得6张10和6张CSLT图像以及4张立体视盘照片。对于每只眼睛每组10和15张图像（以及每只猴子7-25次成像会话中的每一个），计算了37个CSLT参数。单变量更改要求单个参数的更改超出其对方差确定的最小可检测更改（MDC）值的分析范围。多变量更改要求将三个参数组合在一起考虑，以证明通过多变量方差分析确定的显着更改。使用单行策略（单次更改）和两行确定两个参数和一组三参数组合的假阳性变化检测率12个不变的对侧正常眼睛的激光后图像中的策略（连续两次更改）。然后，仅针对临床特定的那些参数和三参数组合评估研究眼睛图像中的变化检测（即，正常眼睛中假阳性变化检测不到10％）。结果：总共进行了36次激光前（每只猴子3次）成像和158次激光后（4-22只/猴子）成像。临床特异性变化检测（假阳性率低）仅通过两行合一的策略才能实现。总体而言，多元ONH表面变化检测效果最好;表现最佳的三参数组合在对侧正常眼睛的激光后成像时段内的139个成像时段中仅检测到8个变化事件（4个发作和4个进程），而在对侧正常眼内总共检测到47个变化事件（11个发作和36个进程）。 12个研究眼睛的激光后成像会议。在研究眼睛的后期激光成像后阶段中，大多数参数都发生了违反直觉的（前部）变化，继而达到了终末期损害。结论：在纵向获取的CSLT图像中，临床上特异性检测青光眼ONH表面改变的发生和进展是可能的。

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