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首页> 外文期刊>Ophthalmology >A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children.
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A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children.

机译：评估儿童每天两小时斜视和屈光参差性弱视的随机试验。

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OBJECTIVE: To compare 2 hours of daily patching (combined with 1 hour of concurrent near visual activities) with a control group of spectacle wear alone (if needed) for treatment of moderate to severe amblyopia in children 3 to 7 years old. DESIGN: Prospective randomized multicenter clinical trial (46 sites). PARTICIPANTS: One hundred eighty children 3 to 7 years old with best-corrected amblyopic-eye visual acuity (VA) of 20/40 to 20/400 associated with strabismus, anisometropia, or both who had worn optimal refractive correction (if needed) for at least 16 weeks or for 2 consecutive visits without improvement. INTERVENTION: Randomization either to 2 hours of daily patching with 1 hour of near visual activities or to spectacles alone (if needed). Patients were continued on the randomized treatment (or no treatment) until no further improvement was noted. MAIN OUTCOME MEASURE: Best-corrected VA in the amblyopic eye after 5 weeks. RESULTS: Improvement in VA of the amblyopic eye from baseline to 5 weeks averaged 1.1 lines in the patching group and 0.5 lines in the control group (P = 0.006), and improvement from baseline to best measured VA at any visit averaged 2.2 lines in the patching group and 1.3 lines in the control group (P<0.001). CONCLUSION: After a period of treatment with spectacles, 2 hours of daily patching combined with 1 hour of near visual activities modestly improves moderate to severe amblyopia in children 3 to 7 years old.
机译：目的：比较每天配戴2小时（与同时进行1小时近距离视觉活动）和仅配戴眼镜（如果需要）的对照组，以治疗3至7岁儿童的中度至重度弱视。设计：前瞻性随机多中心临床试验（46个地点）。参加者：180名3至7岁的儿童，其最佳矫正弱视视力（VA）为20/40至20/400，与斜视，屈光参差或两者均佩戴了最佳屈光矫正（如果需要）有关至少16周或连续2次就诊而无改善。干预措施：随机分配至每天2小时的贴片和1小时的近距离视觉活动，或随机分配给眼镜（如果需要）。患者继续接受随机治疗（或不接受治疗），直到没有发现进一步改善为止。主要观察指标：5周后弱视的最佳矫正视力。结果：弱视眼从基线到5周的VA改善在贴片组平均为1.1线，对照组为0.5线（P = 0.006），而在每次就诊时从基线到最佳测量VA的改善平均为2.2线。修补组和对照组中的1.3行（P <0.001）。结论：经过一段时间的眼镜治疗后，每天2个小时的修补和1个小时的近视活动可适度改善3至7岁儿童的中度至重度弱视。

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