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Gold nanocages as contrast agents for spectroscopic optical coherence tomography

机译:金纳米笼用作光谱光学相干断层扫描的造影剂

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摘要

We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approx35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.
机译:我们将金纳米笼描述为用于光谱光学相干断层扫描(OCT)的一类新的潜在造影剂。边缘长度约为35 nm的单分散金纳米笼呈现出强烈的光学共振,其峰值波长可在近红外范围内调节。我们通过使用OCT实验以及数值计算来表征纳米笼的光学性质,发现其吸收截面比常规染料大约5个数量级。组织体模的实验表明,纳米笼可以为光谱以及传统的基于强度的OCT成像提供增强的对比度。

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