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Extraction of optical scattering parameters and attenuation compensation in optical coherence tomography images of multilayered tissue structures

机译:多层组织结构的光学相干断层扫描图像中光散射参数的提取和衰减补偿

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摘要

A recently developed analytical optical coherence tomography (OCT) model [Thrane et al., J. Opt. Soc. Am. A 17, 484 (2000)] allows the extraction of optical scattering parameters from OCT images, thereby permitting attenuation compensation in those images. By expanding this theoretical model, we have developed a new method for extracting optical scattering parameters from multilayered tissue structures in vivo. To verify this, we used a Monte Carlo (MC) OCT model as a numerical phantom to simulate the OCT signal for heterogeneous multilayered tissue. Excellent agreement between the extracted values of the optical scattering properties of the different layers and the corresponding input reference values of the MC simulation was obtained, which demonstrates the feasibility of the method for in vivo applications. This is to our knowledge the first time such verification has been obtained, and the results hold promise for expanding the functional imaging capabilities of OCT.
机译:最近开发的分析光学相干断层扫描(OCT)模型[Thrane et al。,J. Opt。 Soc。上午。 17、484(2000)]允许从OCT图像中提取光学散射参数,从而允许在那些图像中进行衰减补偿。通过扩展该理论模型,我们开发了一种从体内多层组织结构中提取光学散射参数的新方法。为了验证这一点,我们使用了蒙特卡洛(MC)OCT模型作为数值模型来模拟异质多层组织的OCT信号。在不同层的光散射特性的提取值与MC模拟的相应输入参考值之间获得了极好的一致性,这证明了该方法在体内应用的可行性。据我们所知,这是第一次获得这种验证,其结果有望扩展OCT的功能成像功能。

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