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首页> 外文期刊>Biological & pharmaceutical bulletin >Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats.
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Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats.

机译：田鼠（Tinospora cordifolia）酒精提取物对大鼠缺血再灌注所致心肌梗死的保护作用。

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摘要

It has been suggested that the beneficial effects of reperfusing the myocardium might be in part reversed by the occurrence of reperfusion injury. Oxidative stress was suggested to be implicating in the pathogenesis of ischemia-reperfusion (I/R) injury. Many antioxidative plants were shown to be cardioprotective in experimental models of myocardial ischemia-reperfusion (I/R) injury. The present study was designed to investigate the effects of pretreatment with alcoholic extract of Tinospora cordifolia in an in vivo rat model. The model adopted was that of surgically-induced myocardial ischemia, performed by means of left anterior descending coronary artery occlusion (LAD) for 30 min followed by reperfusion for another 4 h. Infarct size was measured by using the staining agent TTC (2,3,5-triphenyl tetrazolium chloride). Lipid peroxide levels in serum and in heart tissue were estimated spectrophotometrically by the methods developed by Yagi and Ohkawa et al. respectively. A lead II electrocardiogram was monitored at various intervals throughout the experiment. A dose dependent reduction in infarct size and in lipid peroxide levels of serum and heart tissue were observed with the prior treatment of T. cordifolia with various doses for 7 d compared to control animals. Hence, the present study suggests the cardioprotective activity of T. cordifolia in limiting ischemia-reperfusion induced myocardial infarction.
机译：已经提出，再灌注心肌的有益作用可能会因再灌注损伤的发生而部分逆转。提示氧化应激与缺血再灌注（I / R）损伤的发病机制有关。在心肌缺血再灌注（I / R）损伤的实验模型中，许多抗氧化植物被证明具有心脏保护作用。本研究旨在研究在体内大鼠模型中用心叶青牛耳的酒精提取物进行预处理的效果。采用的模型是外科手术诱发的心肌缺血，通过左前降支冠状动脉闭塞（LAD）进行30分钟，然后再灌注4 h。通过使用染色剂TTC（2,3,5-三苯基氯化四氮唑）测量梗塞面积。血清和心脏组织中的脂质过氧化物水平通过Yagi和Ohkawa等人开发的方法用分光光度法估算。分别。在整个实验过程中，均以不同的间隔对Lead II心电图进行监测。与对照动物相比，用不同剂量的虫草连续处理7天后，观察到梗塞面积和血清及心脏组织脂质过氧化物水平呈剂量依赖性降低。因此，本研究表明堇青树在限制局部缺血-再灌注引起的心肌梗塞中的心脏保护活性。

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