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首页> 外文期刊>Oral oncology >Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features.
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Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features.

机译：口腔癌发生过程中TAOS1和EMS1基因的扩增：与临床病理特征相关。

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摘要

Amplification of chromosomal region 11q13 is one of the genetic alterations most frequently observed in oral squamous cell carcinoma (OSCC). Both TAOS1, a recently identified gene, and EMS1 were thought as two important target oncogenes for driving 11q13 amplification, and their contributions to oral carcinogenesis were hypothesized. Therefore we investigated amplifications of TAOS1 and EMS1 genes and their relations to clinicopathological variables in premalignant lesions (leukoplakias) and primary OSCC. TAOS1 amplification, beginning from mild-dysplastic epithelia, occurred in 33.3% of leukoplakias and 51.5% of OSCC. EMS1 amplification, beginning from moderate-dysplastic epithelia, occurred in 20% of leukoplakias and 57.6% of OSCC. Both gene amplifications were significantly related to different stages of oral carcinogenesis (p<0.05). During multistage carcinogenesis, no gene amplification was observed in normal tissue and non-dysplastic leukoplakias while, in OSCC with metastasis, amplification frequency increased significantly (p<0.005). Both TAOS1 and EMS1 amplifications were significantly associated with larger tumor size, presence of lymph node metastasis, poor histological differentiation and advanced clinical stage. Our data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC.
机译：染色体区域11q13的扩增是口腔鳞状细胞癌（OSCC）中最常见的遗传改变之一。最近发现的TAOS1基因和EMS1被认为是驱动11q13扩增的两个重要靶癌基因，并假设它们对口腔癌变的贡献。因此，我们研究了TAOS1和EMS1基因的扩增及其与癌前病变（白斑）和原发性OSCC中临床病理变量的关系。从轻度异常增生的上皮细胞开始，TAOS1扩增发生在33.3％的白斑和51.5％的OSCC中。从中度异常增生的上皮开始，EMS1扩增发生在20％的白斑和57.6％的OSCC中。两种基因扩增均与口腔癌发生的不同阶段显着相关（p <0.05）。在多阶段癌变过程中，在正常组织和非增生性白斑中未观察到基因扩增，而在有转移的OSCC中，扩增频率显着增加（p <0.005）。 TAOS1和EMS1扩增均与更大的肿瘤大小，淋巴结转移的存在，不良的组织学分化和晚期临床阶段显着相关。我们的数据表明在口腔癌发生过程中潜在的作用，TAOS1可能比EMS1更早参与。这两个基因可能是OSCC诊断和预后的候选生物标志物。

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