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Aggravation of inflammatory bowel diseases by oral streptococci

机译：口服链球菌加重炎症性肠病

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Objectives: Streptococcus mutans can aggravate colitis in mice. We evaluated the virulence of colitis using type strains as well as blood isolates of several oral streptococcal species. Materials and Methods: We investigated the susceptibility of blood isolates of several oral streptococci to phagocytosis, adhesion to and invasion of hepatic cells and interferon-γ secretion. A mouse model of dextran sodium sulphate-induced colitis was used to evaluate bacterial aggravation of colitis. In addition, interferon-γ antibody was administered to mice with prominent aggravation of colitis. Results: In vitro analyses showed that Streptococcus sanguinis ATCC 10556 was a possible virulent strain among type strains of several oral streptococci, and that analysis of blood isolates of S. sanguinis TW289 revealed a potential virulent strain. Intravenous administration of ATCC 10556 and TW289 caused prominent aggravation of dextran sodium sulphate-induced colitis, and histopathological examinations showed that interferon-γ secretion due to infection of hepatic cells caused colitis aggravation. Administration of interferon-γ antibody suppressed TW289-induced colitis. Conclusion: These results suggest that some virulent oral streptococcal strains are associated with the aggravation of colitis induced by enhanced secretion of interferon-γ when they invade the bloodstream.
机译：目的：变形链球菌可加重小鼠结肠炎。我们使用类型菌株以及几种口服链球菌的血液分离株评估了结肠炎的毒性。材料和方法：我们调查了几种口服链球菌的血液分离物对吞噬作用，对肝细胞的粘附和侵袭以及干扰素-γ分泌的敏感性。葡聚糖硫酸钠诱导的结肠炎的小鼠模型用于评估结肠炎的细菌加重。另外，对患有明显结肠炎加重的小鼠给予干扰素-γ抗体。结果：体外分析表明，在几种口服链球菌的类型菌株中，血链球菌ATCC 10556是一种可能的强毒株，对血红链球菌TW289的血液分离株的分析显示这是一种潜在的强毒株。静脉内施用ATCC 10556和TW289引起右旋糖酐硫酸钠诱发的结肠炎的严重加重，并且组织病理学检查显示，由于肝细胞感染引起的干扰素-γ分泌导致结肠炎加重。干扰素-γ抗体的给药可抑制TW289诱导的结肠炎。结论：这些结果表明，某些强毒的口服链球菌菌株与干扰素-γ侵入血液时增强分泌所致的结肠炎加重有关。

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