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首页> 外文期刊>Oral oncology >Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification.
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Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification.

机译：通过多重连接依赖探针扩增，原发性喉癌和咽癌及其匹配的淋巴结转移之间的遗传差异。

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摘要

Lymph nodes metastasis is a major risk factor related to poor survival in larynx and pharynx carcinomas. The aim of this study is to search for markers of lymph node involvement analyzing the genetic differences between primary larynx and pharynx squamous cell carcinomas and their corresponding lymph node metastases. Twenty-five primary tumors and their corresponding lymph node metastases were examined. DNA copy number changes of 37 genes were analyzed by multiplex ligation-dependent probe amplification (MLPA). Loss of CDKN2A (9p21) occurred in 14 out of 25 pairs (56%) of primary tumor and lymph node metastases. Loss of LMNA (1q21) was exclusively detected in 8 lymph node samples (32%). Loss of CTNNB1 (3p22) and gain of CDKN2D (19p13) were also significantly more frequent in lymph node metastases. Other aberrations related to lymph node metastases were loss of MFHAS1 (8p23), RECQL4 (8q24) and gain of N33 (8p22) and TP53 (17p13). Primary tumor and corresponding lymph node metastases showed common genetic changes. However, the lymph node metastases presented with a number of additional alterations. Acquisition of these alterations may play a role in lymphatic metastasis development.
机译：淋巴结转移是与喉癌和咽癌生存不良有关的主要危险因素。这项研究的目的是寻找淋巴结受累的标志物，以分析原发性喉癌和咽鳞状细胞癌及其相应的淋巴结转移之间的遗传差异。检查了二十五个原发性肿瘤及其相应的淋巴结转移。通过多重连接依赖性探针扩增（MLPA）分析了37个基因的DNA拷贝数变化。 25对原发性肿瘤和淋巴结转移中，有14对（56％）发生CDKN2A（9p21）丢失。仅在8个淋巴结样本（32％）中检测到LMNA的丢失（1q21）。在淋巴结转移中，CTNNB1（3p22）的丧失和CDKN2D（19p13）的获得也显着增加。与淋巴结转移相关的其他畸变是MFHAS1（8p23），RECQL4（8q24）的丢失和N33（8p22）和TP53（17p13）的增加。原发肿瘤和相应的淋巴结转移显示常见的遗传变化。但是，淋巴结转移伴有许多其他改变。这些改变的获得可能在淋巴转移的发生中起作用。

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