Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw' by Ziebart T et al. (2011).

Marcuzzi A; Zanin V; Crovella S; Pontillo A

首页> 外文期刊>Oral oncology >Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw' by Ziebart T et al. (2011).

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Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw' by Ziebart T et al. (2011).

机译：Ziebart T等人（2011）对``Geranylgeraniol-一种新的潜在的双膦酸酯相关性颌骨坏死性治疗方法''的评论。

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We read the article "Geranylgeraniol - A new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw" in Oral Oncology, by Ziebart T et al., and would like to compare and discuss these results with our recently published data.The design of the two studies is very similar: natural isopre-noids have been used to revert the mevalonate pathway inhibition induced by amino-bisphosphonates (N-BPs). Isoprenoid compounds are hypothesized to enter the mevalonate pathway after the N-BPs block, being metabolized as farnesyl-pyrophosphate and bypass the biochemical inhibition mediate by N-BPs on farnesyl-pyrophosphate synthase, restoring the metabolites flux along the pathway.

机译：我们阅读了Ziebart T等人在《口腔肿瘤学》上发表的文章“ Geranylgeraniol-一种新的治疗双膦酸酯相关性颌骨坏死的潜在治疗方法”，并希望将这些结果与我们最近发表的数据进行比较和讨论。两项研究非常相似：天然异戊二烯已用于恢复由氨基双膦酸酯（N-BPs）诱导的甲羟戊酸途径的抑制作用。假设类异戊二烯化合物在N-BP阻断后进入甲羟戊酸途径，被代谢为法呢基-焦磷酸，并绕过N-BP在法呢基-焦磷酸合酶上的生化抑制作用，恢复了沿途径的代谢物通量。

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《Oral oncology》 |2011年第5期|共3页
作者
Marcuzzi A; Zanin V; Crovella S; Pontillo A;
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1. Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw" by Ziebart T et al. (2011). [J] . Marcuzzi A, Zanin V, Crovella S, Oral oncology . 2011,第5期

机译：Ziebart T等人（2011）对``Geranylgeraniol-一种新的潜在的双膦酸酯相关性颌骨坏死性治疗方法''的评论。
2. Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw. [J] . Ziebart T, Koch F, Klein MO, Oral oncology . 2011,第3期

机译：Geranylgeraniol-一种新的潜在治疗方法，可治疗双膦酸酯相关性颌骨坏死。
3. Comment on Narv??ez et al.: Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw [J] . SubramanianG., QuekS.Y.P. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA . 2013,第2期

机译：对Narv ?? ez等人的评论：对双膦酸盐相关的颌骨坏死对teriparatide治疗缺乏反应
4. Management of bisphosphonate related jaw osteonecrosis: a review of 19 cases [C] . Ianes E, Streian F, Talpos S, European Association of Cranio-Maxillo-Facial Surgery . 2010

机译：双膦酸盐相关颌骨骨折的管理：综述19例
5. Dental Disease and Bisphosphonates Induce Osteonecrosis of the Jaws in Animal Models [D] . Kang, Benjamin 2012

机译：牙齿疾病和双膦酸盐诱导动物模型中颌骨的骨坏死
6. Comments on Cutaneous Abscess as a Complication of Bisphosphonate-Related Osteonecrosis of the Jaw by Yang et al. [O] . Atousa Hakamifard 2019

机译：杨等人对皮肤脓肿作为颌骨双膦酸二族相关骨折的并发症评论。
7. Alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw: response to comments by Taguchi [O] . Y. Takaishi, T. Ikeo, M. Nakajima, 2009

机译：牙槽骨密度测量在双膦酸酯相关性颌骨坏死风险评估中的作用：Taguchi对评论的回应

Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw' by Ziebart T et al. (2011).

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