...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oral oncology >Retrospective analysis of the impact of HPV status and smoking on mucositis in patients with oropharyngeal squamous cell carcinoma treated with concurrent chemotherapy and radiotherapy
【24h】

Retrospective analysis of the impact of HPV status and smoking on mucositis in patients with oropharyngeal squamous cell carcinoma treated with concurrent chemotherapy and radiotherapy

机译：HPV状态和吸烟对口咽鳞癌同时化疗和放疗患者黏膜炎影响的回顾性分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives The standard concurrent radiotherapy and chemotherapy regimens for patients with oropharyngeal cancer are highly toxic. Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has recently emerged as a distinct biological and clinical entity with improved response to treatment and prognosis. A tailored therapeutic approach is needed to optimize patient care. The aim of our study was to investigate the impact of HPV and smoking status on early toxicities (primarily mucositis) associated with concurrent chemotherapy and radiotherapy in patients with OPSCC. Materials and methods We retrospectively evaluated 72 consecutive patients with OPSCC and known HPV status treated with concurrent radiotherapy and chemotherapy at our institution. Treatment-related toxicities were stratified by smoking and HPV status and compared using univariate and multivariate logistic regression. Results HPV-positive patients had a 6.86-fold increase in the risk of having severe, grade 3-4 mucositis. This effect was preserved after adjusting for patient smoking status, nodal stage, radiotherapy technique and radiotherapy maximum dose. Additionally, HPV status had significant effect on the objective weight loss during treatment and at three months after treatment. Consistently, non-smokers had a significant 2.70-fold increase in the risk of developing severe mucositis. Conclusion Risk factors for OPSCC modify the incidence of treatment-related early toxicities, with HPV-positive and non-smoking status correlating with increased risk of high grade mucositis and associated outcomes. Retrospective single-institution studies need to be interpreted cautiously. However, this finding is important to consider when designing therapeutic strategies for HPV-positive patients and merits further investigation in prospective clinical trials.
机译：目的口咽癌患者的标准同时放疗和化疗方案具有剧毒。人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）最近作为一种独特的生物学和临床实体出现，对治疗和预后的反应有所改善。需要一种量身定制的治疗方法来优化患者护理。我们的研究目的是调查HPV和吸烟状况对OPSCC患​​者同时进行化疗和放疗相关的早期毒性（主要是粘膜炎）的影响。材料和方法我们回顾性评估了本院连续72例OPSCC且已知同时接受放疗和化疗治疗的HPV状况的患者。通过吸烟和HPV状况对与治疗相关的毒性进行分层，并使用单因素和多因素logistic回归进行比较。结果HPV阳性患者发生严重3-4级粘膜炎的风险增加了6.86倍。调整患者的吸烟状况，结节分期，放疗技术和放疗最大剂量后，该效果得以保留。此外，HPV状况对治疗期间和治疗后三个月的客观体重减轻有重大影响。一致地，不吸烟者患严重粘膜炎的风险显着增加了2.70倍。结论OPSCC的危险因素会改变与治疗有关的早期毒性的发生率，HPV阳性和非吸烟状态会增加高级别粘膜炎的风险和相关结果。回顾性单机构研究需要谨慎解释。但是，在为HPV阳性患者设计治疗策略时应考虑这一发现，并值得在前瞻性临床试验中进行进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号