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首页> 外文期刊>Oral oncology >Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer.
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Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer.

机译：与肿瘤相关的成纤维细胞是肿瘤微环境的参数，在移动性舌癌患者的预后方面克服了与癌症相关的参数。

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摘要

Mobile tongue squamous cell carcinoma (MTSCC) is known for its strong propensity for regional metastasis and poor patient survival despite aggressive treatment, thus calling for new and reliable markers for predicting prognosis and guiding therapeutic management. Towards this end, three classes of markers were investigated: cancer-associated fibroblasts (CAFs; alpha-SMA positivity) as a representative of the tumor microenvironment, maspin (mammary serine protease inhibitor) as a tumor marker likely to be modulated by factors within the tumor microenvironment, and DNA content and Ki-67 labeling index as inbuilt tumor markers in 128 cases of MTSCC using immunohistochemistry and image cytometry. Of these markers, only CAF density was independently and relatively strongly associated with elevated mortality from MTSCC. The hazard ratio in the CAF-rich type of tumor microenvironment was 4.85 (95% CI 1.41-16.6, versus the CAF-poor) when adjusted by proportional hazards modeling for the center where the patient was managed, gender, tumor stage, presence of neck metastasis and age at diagnosis. CAF density was unrelated to non-MTSSC mortality. Given the strong association between increased CAF density and higher mortality in MTSCC, routine assessment of CAF density for disease course prognosis and inclusion as an integral part of treatment protocols are recommended.
机译：移动舌状鳞状细胞癌（MTSCC）以其极强的区域转移倾向和尽管积极的治疗方法仍然难以存活的患者而闻名，因此需要新的可靠的标志物来预测预后并指导治疗管理。为此，研究了三类标记物：代表肿瘤微环境的癌症相关成纤维细胞（CAFs;α-SMA阳性），作为肿瘤标记物的maspin（乳腺丝氨酸蛋白酶抑制剂）可能受内在因素的调节。免疫组织化学和图像细胞术检测128例MTSCC患者的肿瘤微环境以及DNA含量和Ki-67标记指数作为内在肿瘤标记物。在这些标志物中，只有CAF密度与MTSCC死亡率升高相关且相对独立。通过按比例风险模型对患者所在的治疗中心，性别，肿瘤分期，是否存在肿瘤进行了比例风险校正后，富含CAF的肿瘤微环境的风险比为4.85（95％CI为1.41-16.6，而CAF较差）。颈部转移和诊断时的年龄。 CAF密度与非MTSSC死亡率无关。鉴于MTSCC中CAF密度的增加与较高的死亡率之间有很强的联系，建议对CAF密度进行常规评估以进行病程预后，并将其纳入治疗方案中。

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