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首页> 外文期刊>Oral oncology >Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma
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Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma

机译：血清胎盘生长因子水平升高与口腔鳞状细胞癌的进展，复发和不良预后密切相关

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We recently found that the expression of placenta growth factor (PlGF) in oral squamous cell carcinoma (OSCC) specimens is correlated with the progression and prognosis of OSCC. In this study, serum samples were obtained from 72 OSCC patients before and 3 months after surgical cancer excision and from 30 normal controls. Serum PlGF levels were determined by enzyme-linked immunosorbent assay (ELISA). The mean serum PlGF levels were significantly higher in pre-surgery OSCC patients than in normal controls (19.1 ± 10.7 vs. 10.1 ± 4.5, P < 0.001). Serum PlGF levels dropped to near the normal control levels after surgical cancer removal. Higher pre-surgery serum PlGF levels were significantly associated with larger tumor size (P = 0.015), positive lymph node metastasis (P = 0.001), more advanced clinical stages (P = 0.002), and loco-regional recurrence (P = 0.037). The serum PlGF level was identified as an independent unfavorable prognosis factor by multivariate Cox regression analyses (P = 0.014). Kaplan-Meier curve showed that OSCC patients with a higher serum PlGF level had a significantly poorer cumulative recurrence-free survival than those with a lower serum PlGF level (log-rank test, P = 0.009). When we used the serum PlGF level of 19.1 pg/ml (mean normal control value plus 2 standard deviations) as a cutoff point, the sensitivity, specificity, and positive predictive value for tumor recurrence was 80%, 56% and 78%, respectively. We conclude that the serum PlGF level may be a valuable biomarker for prediction of therapeutic effect, progression, recurrence and prognosis of OSCC.
机译：我们最近发现，口腔鳞状细胞癌（OSCC）标本中胎盘生长因子（PlGF）的表达与OSCC的进展和预后相关。在这项研究中，从手术切除癌症的患者之前和之后3个月的72例OSCC患者以及30例正常对照中获取血清样品。通过酶联免疫吸附测定（ELISA）确定血清PlGF水平。术前OSCC患者的平均血清PlGF水平显着高于正常对照组（19.1±10.7 vs. 10.1±4.5，P <0.001）。手术切除癌症后，血清PlGF水平降至正常对照水平附近。较高的术前血清PlGF水平与更大的肿瘤大小（P = 0.015），淋巴结转移阳性（P = 0.001），更晚期的临床分期（P = 0.002）和局部复发（P = 0.037）显着相关。通过多因素Cox回归分析将血清PlGF水平确定为独立的不良预后因素（P = 0.014）。 Kaplan-Meier曲线显示，血清PlGF水平较高的OSCC患者的累积无复发生存率明显低于血清PlGF水平较低的患者（对数秩检验，P = 0.009）。当我们使用血清PlGF水平19.1 pg / ml（平均正常对照值加2个标准差）作为临界点时，肿瘤复发的敏感性，特异性和阳性预测值分别为80％，56％和78％。 。我们得出结论，血清PlGF水平可能是预测OSCC的治疗效果，进展，复发和预后的有价值的生物标志物。

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