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Anaplastic thyroid cancer

机译：间变性甲状腺癌

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Purpose Anaplastic thyroid cancer (ATC) is a lethal disease causing a global disproportionate number of thyroid cancer-related deaths. The American Thyroid Association (ATA) has recently produced clear and comprehensive guidelines to assist physicians treating ATC. Methods The recent ATA guideline publication was reviewed. A systematic review of studies indexed in Medline and Pubmed was also undertaken using search terms relevant to ATC. Results Patients with ATC have a median survival of 5 months and less than 20% survive 1 year. Early tumor dissemination results in 20-50% percent of patients having distant metastases and 90% having adjacent tissue invasion on presentation. This highlights the necessity for effective combined therapy. Stage IVA/ IVB, resectable disease may benefit from a multimodal (surgery, IMRT for loco regional control, and systemic therapy) approach. However, a majority of patients present with unresectable locoregional disease. Early palliative care involvement is inclusive of life-prolonging therapies. ATC management demands rapid, complex and integrated multidisciplinary decision making. Conclusion In this article we discuss the multidisciplinary strategies that exist to optimize the management of these patients in accordance with the recent guidelines from The American Thyroid Association.
机译：目的间变性甲状腺癌（ATC）是一种致死性疾病，导致与甲状腺癌相关的全球死亡人数不成比例。美国甲状腺协会（ATA）最近制定了明确而全面的指南，以协助医生治疗ATC。方法回顾了最近的ATA指南出版物。还使用与ATC相关的搜索词对在Medline和Pubmed中索引的研究进行了系统的综述。结果ATC患者中位生存期为5个月，不到20％生存1年。早期肿瘤扩散导致20-50％的患者出现远处转移，90％的患者在出现时有邻近组织浸润。这突出了有效联合治疗的必要性。在IVA / IVB期，可切除疾病可能受益于多模式（手术，用于局部区域控制的IMRT和全身治疗）方法。但是，大多数患者存在不可切除的局部区域性疾病。早期姑息治疗的参与包括延长生命的疗法。 ATC管理需要快速，复杂和集成的多学科决策。结论在本文中，我们讨论了根据美国甲状腺协会最近的指南优化这些患者管理的多学科策略。

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