首页> 外国专利> ANAPLASTIC THYROID CANCERS HARBOR NOVEL ONCOGENIC MUTATIONS OF THE ALK GENE

ANAPLASTIC THYROID CANCERS HARBOR NOVEL ONCOGENIC MUTATIONS OF THE ALK GENE

机译:无性甲状腺癌癌基因的致癌突变

摘要

The present invention relates to diagnostic, therapeutic and prognostic methods for thyroid cancers. In one embodiment, the present invention provides a method for treating a an anaplastic thyroid cancer (ATC) patient comprising the step of administering to the patient an effective amount of an anaplastic lymphoma kinase (ALK) inhibitor. In another embodiment, a method for diagnosing ATC in patient comprises the step of performing an assay on a biological sample from the patient to identify the presence or absence of a C3592T and/or a G3602A mutation in exon 23 of the ALK gene according to SEQ ID NO:6, wherein the presence of either of both of the mutations correlates with a diagnosis of ATC in the patient.
机译:本发明涉及甲状腺癌的诊断,治疗和预后方法。在一个实施方案中,本发明提供了一种用于治疗变性甲状腺癌(ATC)患者的方法,该方法包括对患者施用有效量的变性淋巴瘤激酶(ALK)抑制剂的步骤。在另一个实施方案中,用于诊断患者中ATC的方法包括以下步骤:对来自患者的生物样品进行测定,以鉴定根据SEQ ID NO:23的ALK基因的外显子23中是否存在C3592T和/或G3602A突变。 ID NO:6,其中两个突变中任一个的存在与患者中ATC的诊断相关。

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