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首页> 外文期刊>Oral diseases >Presence of Porphyromonas gingivalis and plasma cell dominance in gingival tissues with periodontitis.
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Presence of Porphyromonas gingivalis and plasma cell dominance in gingival tissues with periodontitis.

机译：牙周炎的牙龈组织中牙龈卟啉单胞菌的存在和浆细胞的优势。

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OBJECTIVE: Porphyromonas gingivalis can invade and survive within its host epithelial cells. The aim of this study was to test our hypothesis that persistent presence of intracellular periodontal pathogens in gingival tissue causes the chronic inflammation and that an inappropriate immune response is a risk factor for periodontitis. METHODS: Together with the presence of P. gingivalis, the distribution of B cells, plasma cells, and CD4(+), CD8(+), and FOXP3(+) regulatory T cells was evaluated in gingival tissues from healthy (n = 7) and periodontitis (n = 8) sites by in situ hybridization and immunohistochemistry, respectively. RESULTS: Porphyromonas gingivalis was detected in proximity to inflammatory infiltrates in three and seven biopsies from the healthy and periodontitis sites, respectively. Compared with healthy sites, periodontal lesions contained a significantly increased number of each immune cell studied with a relative dominance of plasma cells over T cells. CONCLUSIONS: Persistent bacterial invasion of gingival tissues in combination with a plasma cell-dominant immune response may be involved in the pathogenesis of periodontitis.
机译：目的：牙龈卟啉单胞菌可在其宿主上皮细胞内侵袭并生存。这项研究的目的是检验我们的假设，即牙龈组织中细胞内牙周病原体的持续存在会引起慢性炎症，而不适当的免疫反应是牙周炎的危险因素。方法：结合牙龈卟啉单胞菌的存在，评估健康牙龈组织中B细胞，浆细胞以及CD4（+），CD8（+）和FOXP3（+）调节性T细胞的分布（n = 7 ）和牙周炎（n = 8）的位点分别通过原位杂交和免疫组织化学进行。结果：分别在来自健康和牙周炎部位的三个和七个活检组织中，在炎性浸润附近检测到牙龈卟啉单胞菌。与健康部位相比，牙周病变中每个免疫细胞的数量均显着增加，其中浆细胞相对于T细胞具有相对优势。结论：牙龈组织的持久性细菌侵袭结合浆细胞为主的免疫反应可能与牙周炎的发病机制有关。

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