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首页> 外文期刊>Oral oncology >Decrease in mast cells in oral squamous cell carcinoma: possible failure in the migration of these cells.
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Decrease in mast cells in oral squamous cell carcinoma: possible failure in the migration of these cells.

机译：口腔鳞状细胞癌中肥大细胞减少：这些细胞迁移可能失败。

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It is becoming accepted that multiple cell types in stromal microenvironment are involved in tumorigenesis. In this setting, mast cells (MC) display a diversity of roles that may contribute to the defense against tumors or tumor progression. Thus, the aim of this study was to evaluate density and migration of MCs in OSCC (oral squamous cell carcinoma) and pre-malignant oral hyperkeratosis (leukoplakia) as well as their relationship with clinical and microscopic parameters. The tryptase and c-kit expression was analyzed in 38 cases of OSCC, 26 cases of leukoplakia, and 12 cases of clinically healthy oral mucosa (control) by means of immunohistochemistry. The tryptase(+) cell numbers were decreased in OSCC (P=0.0003) and leukoplakia (P=0.03) compared with control. Similar numbers of tryptase(+) cells were observed in leukoplakia and OSCC (P=0.31). The density of c-kit(+) MCs was also significantly lower in OSCC and leukoplakia in relation to control resulting in a reduced c-kit(+)/tryptase(+) relationship in OSCC (19%) in comparison with leukoplakia (59%) and control (63%). No correlation was observed between MC populations with clinical and microscopic characteristics of OSCC. Our findings suggest that the decrease in MC numbers in pre-malignant and malignant oral lesions may be related to the migration failure of these cells, possibly reflecting an important modification in the microenvironment during tumor initiation and progression.
机译：基质微环境中的多种细胞类型都参与了肿瘤的形成，这一点已为人们所接受。在这种情况下，肥大细胞（MC）显示出多种作用，可能有助于防御肿瘤或肿瘤进展。因此，本研究的目的是评估OSCC（口腔鳞状细胞癌）和恶性前口腔过度角化病（白斑）中MC的密度和迁移，以及它们与临床和显微镜参数的关系。通过免疫组织化学分析了38例OSCC，26例白斑和12例临床健康的口腔粘膜（对照）中的类胰蛋白酶和c-kit表达。与对照组相比，OSCC（P = 0.0003）和白斑（P = 0.03）的类胰蛋白酶（+）细胞数量减少。在白斑和OSCC中观察到相似数量的类胰蛋白酶（+）细胞（P = 0.31）。与对照组相比，OSCC和白斑中c-kit（+）MC的密度也显着降低，导致OSCC中的c-kit（+）/胰蛋白酶（+）关系降低（19％）（59） ％）和对照（63％）。 MC人群与OSCC的临床和微观特征之间没有相关性。我们的研究结果表明，恶变前和恶性口腔病变中MC数量的减少可能与这些细胞的迁移失败有关，可能反映了肿瘤发生和发展过程中微环境的重要改变。

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