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首页> 外文期刊>Osteoarthritis and cartilage >Reliability of diffraction enhanced imaging for assessment of cartilage lesions, ex vivo.
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Reliability of diffraction enhanced imaging for assessment of cartilage lesions, ex vivo.

机译：衍射增强成像的可靠性，用于评估离体软骨损伤。

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OBJECTIVE: The assessment of articular cartilage integrity is of value for the detection of early degenerative joint disease in both the clinical and the research settings. It was the purpose of this study to determine the accuracy and reliability of identifying articular cartilage defects through Diffraction Enhanced Imaging (DEI), a high contrast radiographic imaging technique. DEI provides two new sources of image contrast to radiography: refraction and scatter rejection, besides the absorption of conventional radiography. DESIGN: Cadaveric tali were DEI imaged in the anterior-posterior position at the National Synchrotron Light Source. Two independent observers provided gross score evaluations (on a five point scale) of the trochlear surfaces. The DEI image of each trochlear surface was then graded (on a five point scale) by two additional independent observers who were blinded with regard to the gross evaluation of the articular surfaces. Inter-observer agreement for DEI grades was assessed with the weighted kappa statistic. Correlation of diffraction enhanced image score to the gross score was assessed with Spearman correlation coefficient. RESULTS: The defects of articular cartilage of talar trochleae could be visualized through DEI. The Spearman correlation of gross grades with DEI grades on the 165 talar regions for observers 1 and 2 were 0.91 and 0.91, respectively. The overall weighted kappa value for inter-observer agreement was 0.93, thus considered high agreement. CONCLUSIONS: DEI is accurate and reliable for detection of articular cartilage defects ex vivo. Even early stages of degeneration of cartilage can be visualized with this high contrast technique. Future studies will focus on the application of DEI to the identification of such lesions in vivo.
机译：目的：评估关节软骨的完整性对于在临床和研究环境中早期发现退行性关节疾病具有重要意义。这项研究的目的是通过衍射增强成像（DEI）（一种高对比射线照相成像技术）来确定鉴定关节软骨缺损的准确性和可靠性。 DEI提供了两种与放射线照相反差的新图像来源：折射和散射抑制，以及传统放射线照相的吸收。设计：在国家同步加速器光源的前后位置上对尸体塔利进行DEI成像。两名独立的观察员对滑车表面进行了总评分评估（五分制）。然后，由另外两名独立的观察者对每个滑车表面的DEI图像进行分级（按五分制），这些观察者对关节表面的总体评估视而不见。 DEI等级的观察员之间的一致性用加权Kappa统计量进行了评估。用Spearman相关系数评估衍射增强图像得分与总得分的相关性。结果：距骨滑车的关节软骨缺损可通过DEI观察。观察者1和2的165个距骨上总成绩与DEI成绩的Spearman相关性分别为0.91和0.91。观察员之间协议的整体加权kappa值为0.93，因此被认为是较高的协议。结论：DEI准确，可靠地离体检测关节软骨缺损。通过这种高对比度技术，甚至可以观察到软骨退变的早期阶段。未来的研究将集中于DEI在体内鉴定此类病变的应用。

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