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首页> 外文期刊>Osteoarthritis and cartilage >Celecoxib improves the efficiency of the locomotor mechanism in patients with knee osteoarthritis. A randomised, placebo, double-blind and cross-over trial.
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Celecoxib improves the efficiency of the locomotor mechanism in patients with knee osteoarthritis. A randomised, placebo, double-blind and cross-over trial.

机译：塞来昔布提高了膝部骨关节炎患者的运动机制效率。一项随机，安慰剂，双盲和交叉试验。

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摘要

OBJECTIVE: To compare the effect of celecoxib vs placebo treatment on clinical and gait variables in knee osteoarthritis (OA) patients; focusing on the efficiency of the locomotor mechanism. METHODS: STUDY DESIGN: A prospective, randomised, double-blind placebo-controlled trial. PATIENTS: Eight adult patients with painful OA of the knee. OUTCOME MEASURES: Clinical assessment included knee pain assessed by the visual analogue scale, range of knee motion assessed by goniometer, and locomotor function status assessed by a Knee Score Scale. Gait was assessed by means of instrumented analysis including synchronous kinematic, dynamic, electromyographic, and energetic recordings. STATISTICAL ANALYSIS: The effect of treatment on the primary variable, the efficiency of the locomotor mechanism, and on secondary clinical and gait variables was assessed by the Hills and Armitage non-parametric approach. RESULTS: Celecoxib treatment improved the efficiency of the locomotor mechanism significantly. Among the secondary outcome measures assessed, celecoxib treatment improved walking cadence and reduced the knee pain significantly. CONCLUSION: This study shows that celecoxib is effective in improving locomotor function and pain in patients with knee OA.
机译：目的：比较塞来昔布和安慰剂治疗对膝骨关节炎（OA）患者临床和步态变量的影响;关注运动机制的效率。方法：研究设计：一项前瞻性，随机，双盲安慰剂对照试验。患者：八名患有膝关节炎的成人患者。观察指标：临床评估包括通过视觉模拟量表评估膝盖疼痛，通过测角计评估膝关节活动范围以及通过膝关节评分量表评估运动功能状态。通过仪器分析评估步态，包括同步运动，动态，肌电图和能量记录。统计分析：采用希尔斯和阿米蒂奇非参数方法评估了治疗对主要变量，运动机制效率以及继发临床和步态变量的影响。结果：塞来昔布治疗显着提高了运动机制的效率。在评估的次要结局指标中，塞来昔布治疗可改善步行节奏并显着减轻膝盖疼痛。结论：本研究表明塞来昔布可有效改善膝骨关节炎患者的运动功能和疼痛。

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