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首页> 外文期刊>Osteoarthritis and cartilage >A tissue engineering approach to meniscus regeneration in a sheep model.
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A tissue engineering approach to meniscus regeneration in a sheep model.

机译：绵羊模型中半月板再生的组织工程方法。

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OBJECTIVE: Regeneration of the meniscal tissue occurs to a limited extent, and the loss of meniscal tissue leads to osteoarthritis. A new biomaterial consisting of hyaluronic acid and polycaprolactone was used as a meniscus substitute in sheep to evaluate the properties of the implant material with regard to size, biomechanical stability, tissue ingrowth, and integration. METHODS: Eight sheep (right stifle joints) were treated with three total and three partial meniscus replacements while two meniscectomies served as empty controls. The animals were euthanized after 6 weeks. The specimens were assessed by gross inspection and histology, and compared with the nonoperated left joints. RESULTS: The surgical technique was found to be feasible. The implants remained in position, did not tear, and showed excellent tissue ingrowth to the capsule. Tissue integration was also observed between the original meniscus and the implant. However, graft compression and extrusion occurred. The histological investigationrevealed tissue formation, cellular infiltration and vascularization. Cartilage degeneration was more severe in the operated joints. CONCLUSION: The present study shows promising results concerning the qualities of this biomaterial with regard to implantation technique, stability and tissue ingrowth.
机译：目的：半月板组织的再生在一定程度上发生，并且半月板组织的丧失会导致骨关节炎。一种由透明质酸和聚己内酯组成的新型生物材料被用作绵羊的半月板替代品，以评估植入物材料在尺寸，生物力学稳定性，组织向内生长和整合方面的特性。方法：对八只绵羊（右st节关节）进行了三个半月板置换和三个半月板置换治疗，同时将两个半月板切除术作为空对照。 6周后对动物实施安乐死。通过肉眼检查和组织学评估标本，并与未手术的左关节进行比较。结果：手术技术被认为是可行的。植入物保持在原位，没有撕裂，并显示出极好的组织向内生长。在原始弯液面和植入物之间也观察到组织整合。但是，发生了移植物压缩和挤压。组织学检查揭示了组织形成，细胞浸润和血管形成。手术关节的软骨变性更为严重。结论：本研究显示了关于这种生物材料在植入技术，稳定性和组织向内生长方面的质量的有希望的结果。

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