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首页> 外文期刊>Osteoarthritis and cartilage >Osteoarthritis of the knee--clinical assessments and inflammatory markers.
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Osteoarthritis of the knee--clinical assessments and inflammatory markers.

机译：膝骨关节炎-临床评估和炎症标志物。

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OBJECTIVE: The present cross sectional study was performed to test the hypothesis that in osteoarthritis (OA) of the knee severity of this disease is related to local levels of inflammatory metabolites and their corresponding enzymes. METHODS: From 41 patients with OA of the knee (age range 45-79 years) undergoing arthroscopy blood, synovial fluid (SF) and synovial membrane (SM) were collected. Clinical conditions were primarily assessed by the WOMAC-index and radiographic grading (K&L-grade). Concentrations of PGE(2), TxB(2)and NO(2/3)and that of IL-6, IL-1 alpha, IL-1 beta, TNF alpha, COX-2 and iNOS were determined in SF and SM, respectively. RESULTS: With advancing age K&L-grade and COX-2 in SM increased significantly (P=0.005 and P=0.01, respectively). TNF alpha and IL-1 alpha were not detectable in SM samples. Apart from a correlation between PGE(2)and WOMAC-index (r=0.36, P=0.035) no significant relationships could be found between the various inflammatory parameters and any of the assessed clinical signs. CONCLUSIONS: Apparently no direct relationships exist between the measured markers of inflammation (e.g. PGE(2), NO(2/3)) or the involved enzymes (e.g. COX-2, iNOS) and the severity of OA of the knee. The degenerative condition of this disease might be due to the more local, mainly mechanical injury with little systemic upset. However, further longitudinal studies are needed to clarify whether the assessed biochemical markers could serve as predictors for the progression of OA.
机译：目的：进行本项横断面研究以检验以下假说：在骨关节炎（OA）中，该病的严重程度与炎症代谢产物及其相应酶的局部水平有关。方法：从41例膝关节OA患者（年龄范围45-79岁）中接受关节镜检查血，滑液（SF）和滑膜（SM）。临床状况主要通过WOMAC指数和X线照片分级（K＆L级）进行评估。在SF和SM中测定了PGE（2），TxB（2）和NO（2/3）以及IL-6，IL-1 alpha，IL-1 beta，TNFα，COX-2和iNOS的浓度，分别。结果：随着年龄的增长，SM中的K＆L级和COX-2显着增加（分别为P = 0.005和P = 0.01）。在SM样品中未检测到TNF alpha和IL-1 alpha。除了PGE（2）和WOMAC指数之间的相关性（r = 0.36，P = 0.035），各种炎症参数与任何评估的临床体征之间均未发现显着关系。结论：显然，所测量的炎症标志物（例如PGE（2），NO（2/3））或涉及的酶（例如COX-2，iNOS）与膝盖OA的严重程度之间没有直接关系。该疾病的退行性疾病可能是由于局部损伤（主要是机械损伤）和很少的全身不适引起的。然而，需要进一步的纵向研究来阐明所评估的生化标记物是否可以作为OA进展的预测因子。

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