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首页> 外文期刊>Osteoarthritis and cartilage >The effects of intraarticularly injected sodium hyaluronate on levels of intact aggrecan and nitric oxide in the joint fluid of patients with knee osteoarthritis.
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The effects of intraarticularly injected sodium hyaluronate on levels of intact aggrecan and nitric oxide in the joint fluid of patients with knee osteoarthritis.

机译：关节内注射透明质酸钠对膝骨关节炎患者关节液中完整的聚集蛋白聚糖和一氧化氮水平的影响。

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摘要

OBJECTIVE: Intraarticular injections of sodium hyaluronate (Na-HA) appear effective in reducing subjective symptoms of osteoarthritis (OA) and may also have protective effects on the cartilage matrix. The present study analyzed the suppressive effects of Na-HA on the release and degradation of aggrecan and on levels of nitric oxide (NO) in the joint fluid of patients with knee OA. DESIGN: Sixteen OA patients with knee joint effusion were treated by 5 weekly intraarticular injections of Na-HA. Prior to each Na-HA injection, joint fluid was collected to determine the levels of chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate (C6S), intact aggrecan and NO. RESULTS: One week after the final injection, the joint fluid levels of C4S, C6S, and NO were significantly decreased. In contrast, the joint fluid level of intact aggrecan was stable during the series of Na-HA injections. A trend was seen for a positive correlation (P < 0.1) between the clinical score and C4S or C6S joint fluid levels, and for a negative correlation between the joint fluid levels of intact aggrecan and C4S or C6S. No significant correlations were observed between joint fluid levels of NO, the clinical score, and levels of C4S, C6S, and intact aggrecan. CONCLUSION: The results of this study suggest that intraarticularly injected Na-HA is able to improve the clinical symptoms of OA partially based on its ability to reduce the release and degradation of aggrecan and/or to enhance the synthesis of aggrecan in the joint tissues of the patients with knee OA. While Na-HA also reduces the NO level in the joint fluid of patients with knee OA, this effect may be independent from the other effects of Na-HA.
机译：目的：关节腔内注射透明质酸钠（Na-HA）似乎可以有效减轻骨关节炎（OA）的主观症状，并且可能对软骨基质具有保护作用。本研究分析了Na-HA对膝骨关节炎患者关节聚集液中聚集蛋白聚糖的释放和降解以及一氧化氮（NO）水平的抑制作用。设计：对16例OA膝关节积液患者进行了5周每周一次的Na-HA关节腔内注射治疗。在每次注射Na-HA之前，收集关节液以确定4-硫酸软骨素（C4S）和6-硫酸软骨素（C6S），完整的聚集蛋白聚糖和NO的水平。结果：最后一次注射后一周，C4S，C6S和NO的关节液水平显着降低。相反，在一系列的Na-HA注射过程中，完整的聚集蛋白聚糖的关节液水平稳定。临床评分与C4S或C6S关节液水平之间呈正相关（P <0.1），完整的聚集蛋白聚糖与C4S或C6S的关节液之间呈负相关。在关节液的NO水平，临床评分以及C4S，C6S和完整的聚集蛋白聚糖水平之间没有观察到显着相关性。结论：本研究结果表明，关节腔内注射的Na-HA能够部分减少OA的临床症状，这是基于其减少软骨聚集蛋白聚糖的释放和降解和/或增强软骨组织中软骨聚集蛋白聚糖合成的能力。膝骨关节炎患者。尽管Na-HA还可以降低膝OA患者关节液中的NO水平，但这种作用可能与Na-HA的其他作用无关。

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