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首页> 外文期刊>Osteoarthritis and cartilage >Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria.
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Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria.

机译：膝关节和髋骨关节炎的血清和尿液生化标志物：应用共识性BIPED标准的系统评价。

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CONTEXT: Molecules that are released into biological fluids during matrix metabolism of articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers of the process of osteoarthritis (OA). Unfortunately, actual breakthroughs in the biochemical OA marker field are limited so far. OBJECTIVE: By reviewing the status of commercially available biochemical OA markers according to the "Burden of disease, Investigative, Prognostic, Efficacy of intervention, and Diagnostic" ("BIPED") classification, future use of this "BIPED" classification is encouraged and more efficient biochemical OA marker research stimulated. DATA SOURCES: Three electronic databases [PubMed, Scopus, EMBASE (1997-May 2009)] were searched for publications on blood and urinary biochemical markers in human primary knee and hip-OA. STUDY SELECTION: Stepwise selection of original English publications describing human studies on blood or urinary biochemical markers in primary knee or hip-OA was performed. Selected articles were fully read to determine whether biochemical markers were investigated on performance within any of the "BIPED" categories. Eighty-four relevant publications were identified. DATA EXTRACTION: Data from relevant publications were tabulated according to the "BIPED" classification. Individual analyses within a publication were summarized in general "BIPED" scores. DATA SYNTHESIS: An uneven distribution of scores on biochemical marker performance and heterogeneity among the publications complicated direct comparison of individual biochemical markers. Comparison of categories of biochemical markers was therefore performed instead. In general, biochemical markers of cartilage degradation were investigated most extensively and performed well in comparison with other categories of biochemical markers. Biochemical markers of bone metabolism performed less adequately. Biochemical markers of synovial tissue metabolism were not investigated extensively, but performed quite well. CONCLUSIONS: Specific biochemical markers and categories of biochemical markers as well as their nature, origin and metabolism, need further investigation. International standardization of future investigations should be pursued to obtain more high-quality, homogenous data on the full spectrum of biochemical OA markers.
机译：背景：在关节软骨，软骨下骨和滑膜组织的基质代谢过程中释放到生物体液中的分子可以作为骨关节炎（OA）进程的生化标志。不幸的是，到目前为止，生化OA标记物领域的实际突破是有限的。目的：通过根据“疾病负担，调查，预后，干预效果和诊断”（“ BIPED”）分类来审查市售生化OA标记物的状况，鼓励该“ BIPED”分类法的未来使用，以及更多促进了高效的生化OA标记物研究。数据来源：搜索了三个电子数据库[PubMed，Scopus，EMBASE（1997年5月-2009年5月）]，以获取有关人类原发性膝关节和髋骨OA中血液和尿液生化标志物的出版物。研究选择：逐步选择描述人类对原发性膝关节或髋部OA中血液或尿液生化标志物研究的英文原始出版物。完整阅读所选文章，以确定是否对“ BIPED”类别中任何一项的性能进行了生化指标调查。确定了八十四本相关出版物。数据提取：根据“ BIPED”分类，将来自相关出版物的数据制成表格。出版物中的各个分析均以“ BIPED”总评分进行汇总。数据综合：各出版物之间生化标志物性能和异质性得分的不均匀分布使单个生化标志物的直接比较变得复杂。因此，进行了生化标记物类别的比较。通常，对软骨降解的生化标志物进行了最广泛的研究，与其他类别的生化标志物相比，表现良好。骨代谢的生化指标表现不佳。滑膜组织代谢的生化标志物尚未广泛研究，但表现良好。结论：具体的生化标志物和生化标志物的种类及其性质，起源和代谢，需要进一步研究。应当寻求未来研究的国际标准化，以获取有关生化OA标志物全谱的更多高质量，均匀数据。

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