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首页> 外文期刊>Osteoarthritis and cartilage >Identifying different osteoarthritis phenotypes through epidemiology.
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Identifying different osteoarthritis phenotypes through epidemiology.

机译:通过流行病学识别不同的骨关节炎表型。

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The Oxford English Dictionary defines a phenotype as the "sum total of observable characteristics of an individual, regarded as the consequences of the interaction of the individual's genotype and environment; a variety of an organism distinguished by observable characteristics rather than underlying genetic features." Wikipe-dia2 expands this definition to"any observable characteristic or trait of an organism such as its morphology, development, biochemical, or physiologic properties or behavior." One key element of these definitions is that a phenotype is defined by a characteristic that is observable by the naked eye, by images or by blood tests. A genotype is often the source of phenotypic variation, but a genotype is only relevant to phenotypes when it creates an observable difference between two organisms with the same disease; thus a genotype expression can create phenotypic variation when the effect of the genotype is observable.
机译:《牛津英语词典》将表型定义为“一个人的可观察特征的总和,被视为该人的基因型与环境相互作用的结果;各种具有可观察特征而不是基础遗传特征的生物。” Wikipe-dia2将该定义扩展为“生物体的任何可观察特征或特性,例如其形态,发育,生化或生理特性或行为”。这些定义的一个关键要素是,表型是由肉眼,图像或血液检查可观察到的特征定义的。基因型通常是表型变异的源头,但是当基因型在具有相同疾病的两个生物之间产生可观察到的差异时,它仅与表型相关。因此,当可以观察到基因型的影响时,基因型表达可以产生表型变异。

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