...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Osteoarthritis and cartilage >Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.
【24h】

Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.

机译：手部骨关节炎中白细胞介素4 /白细胞介素4受体基因多态性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study. METHODS: Eighteen common single nucleotide polymorphisms (SNPs) (nine in IL-4R, five in IL-4 and four in IL-13) were genotyped in 403 patients (380 females) with hand OA and 322 healthy controls (308 females). RESULTS: Two SNPs (rs1805013 and rs1805015), mapping to the IL-4R gene, were associated with P-values of 0.0116 and 0.0305 respectively in the whole sample. As far as the non-erosive hand OA group (n=159) is concerned, the significance level of association of SNP rs1805013 is increased. After correction for multiple testing (correction for the 54 tests) the significance was not retained. None of the IL-13 SNPs analyzed showed association with hand OA. Some of the analyzed SNP within the IL-4 gene showed significant association with hand OA only when considering subgroups of patients. With respect to the CMC1 OA group, two SNPs in IL-4 (rs2243250 and rs2243274) showed association with a P-value of 0.027 and 0.018 respectively. None of these associations remained after correction for multiple testing. CONCLUSIONS: The present study shows a trend to an association between non-erosive hand OA in Caucasian population and a genetic variant in the coding region of IL-4R gene. Our results, in keeping with previous data on hip OA, confirm the suggestion that IL-4/IL-4R system plays a role in OA pathogenesis. Further confirmation studies on different populations are necessary.
机译：目的：IL-13 / IL-4 / IL-4R系统具有较强的软骨保护活性。通过进行病例对照研究，我们调查了这些基因中的多态性，将其作为潜在的手部骨关节炎（OA）易感基因座。方法：对403例（380例女性）手OA患者和322例健康对照（308例女性）进行了18种常见的单核苷酸多态性（SNPs）（IL-4R中为9个，IL-4中为5个，IL-13中为4个）的基因分型。结果：映射到IL-4R基因的两个SNP（rs1805013和rs1805015）在整个样本中的P值分别为0.0116和0.0305。就非侵蚀性手OA组（n = 159）而言，SNP rs1805013的关联显着性水平得到提高。在针对多个测试进行更正（针对54个测试进行更正）之后，其重要性没有得到保留。分析的IL-13 SNP均未显示与手OA相关。仅当考虑患者亚组时，IL-4基因中某些分析的SNP才显示与手OA显着相关。对于CMC10A组，IL-4中的两个SNP（rs2243250和rs2243274）显示P值分别为0.027和0.018。经过多次测试校正后，这些关联都没有保留。结论：本研究表明高加索人群非侵蚀性手OA与IL-4R基因编码区遗传变异之间存在关联的趋势。我们的结果与先前有关髋骨OA的数据一致，证实了IL-4 / IL-4R系统在OA发病机理中起作用的暗示。有必要对不同人群进行进一步的确认研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号