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首页> 外文期刊>Osteoarthritis and cartilage >Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up
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Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up

机译：早期髋/膝骨关节炎（CHECK）中的皮肤戊糖苷并不是5年随访中影像学进展的强有力的独立预测因子

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摘要

Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in a cohort of early knee and/or hip OA. Design: The 5 years follow-up data of 300 patients from cohort hip & cohort knee (CHECK) were used. Radiographic progression and burden were assessed by X-rays of both knees and hips (Kellgren and Lawrence (K&L) and Altman scores). Baseline pentosidine levels (and urinary CTXII as a comparator) were measured by high-performance-liquid-chromatography (HPLC) and enzyme linked immunosorbent assay (ELISA). Univariable and multivariable associations including baseline radiographic damage, age, gender, body mass index (BMI) and kidney function were performed. Results: Both pentosidine and urinary C-terminal telopeptide of type II collagen (uCTXII) correlated with radiographic progression and burden. In general pentosidine did not have an added predictive value to uCTXII for progression nor burden of the disease. The best prediction was obtained for burden of radiographic damage (R2=0.60-0.88), bus this was predominantly determined by baseline radiographic damage (without this parameter R2=0.07-0.17). Interestingly, pentosidine significantly added to prediction of osteophyte formation, whereas uCTXII significantly added to prediction of JSN in multivariable analysis. Conclusion: Pentosidine adds to prediction of radiographic progression and burden of osteophyte formation and uCTXII to radiographic progression and burden of JSN, but overall skin pentosidine did not perform better that uCTXII in predicting radiographic progression or burden. Burden of damage over 5 years is mainly determined by radiographic joint damage at baseline.
机译：年龄相关的关节软骨变化可能在骨关节炎（OA）的病因中起作用。与年龄相关的主要软骨变化之一是晚期糖基化终末产物（AGEs）的积累。本研究评估了戊糖苷是否可以预测早期膝关节和/或髋关节OA人群在5年随访中的影像学进展和/或负担。设计：使用队列髋关节和队列膝盖（CHECK）的300例患者的5年随访数据。放射学进展和负担通过膝盖和臀部的X射线评估（Kellgren和Lawrence（K＆L）和Altman评分）。通过高效液相色谱（HPLC）和酶联免疫吸附测定（ELISA）测量基线戊糖苷水平（和尿CTXII作为比较物）。进行了单变量和多变量关联，包括基线影像学损害，年龄，性别，体重指数（BMI）和肾功能。结果：II型胶原的戊糖苷和尿C端端肽（uCTXII）均与影像学进展和负担相关。通常，戊糖苷对uCTXII的疾病进展和负担没有附加的预测价值。放射线损伤的负担得到了最好的预测（R2 = 0.60-0.88），这主要是由基线放射线损伤确定的（没有该参数R2 = 0.07-0.17）。有趣的是，在多变量分析中，戊糖苷显着增加了对骨赘形成的预测，而uCTXII显着增加了对JSN的预测。结论：戊糖苷对JSN的影像学进展和负担增加了骨赘形成和uCTXII的放射学进展和负担的预测，但是总体皮肤戊糖苷在预测放射学进展或负担方面的表现不及uCTXII。 5年的损坏负担主要由基线的放射照相关节损伤确定。

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