TGF-beta is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

Davidson E. N. Blaney; van Caam A. P. M.; Vitters E. L.; Bennink M. B.; Thijssen E.; van den Berg W. B.; Koenders M. I.; van Lent P. L. E. M.; van de Loo F. A. J.; van der Kraan P. M.

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TGF-beta is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

机译：TGF-β通过ALK5-Smad2 / 3途径是关节软骨中神经生长因子的有效诱导剂。在OA相关疼痛中的潜在作用？

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Objective: Pain is the main problem for patients with osteoarthritis (OA). Pain is linked to inflammation, but in OA a subset of patients suffers from pain without inflammation, indicating an alternative source of pain. Nerve Growth Factor (NGF) inhibition is very efficient in blocking pain during OA, but the source of NGF is unclear. We hypothesize that damaged cartilage in OA releases Transforming Growth Factor-beta (TGF-beta), which in turn stimulates chondrocytes to produce NGF.

机译：目的：疼痛是骨关节炎（OA）患者的主要问题。疼痛与炎症有关，但在OA中，一部分患者会遭受无炎症的疼痛，这表明存在另一种疼痛来源。神经生长因子（NGF）抑制在阻止OA期间的疼痛方面非常有效，但NGF的来源尚不清楚。我们假设OA中的软骨受损会释放出转化生长因子-β（TGF-beta），从而刺激软骨细胞产生NGF。

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《Osteoarthritis and cartilage》 |2015年第3期|共9页
作者
Davidson E. N. Blaney; van Caam A. P. M.; Vitters E. L.; Bennink M. B.; Thijssen E.; van den Berg W. B.; Koenders M. I.; van Lent P. L. E. M.; van de Loo F. A. J.; van der Kraan P. M.;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Pain; Cartilage; TGF-beta; NGF; Smad;

机译：疼痛;软骨;TGF-beta;NGF;Smad;

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1. TGF-beta IS A POTENT INDUCER OF NERVE GROWTH FACTOR IN ARTICULAR CARTILAGE VIA THE ALK5-SMAD2/3 PATHWAY. POTENTIAL ROLE IN OA RELATED PAIN? [J] . Davidson E. N. Blaney, van Caam A. P., Vitters E. L., Osteoarthritis and cartilage . 2015,第Suppla2期

机译：TGF-β是通过ALK5-SMAD2 / 3途径在关节软骨中引起神经生长因子的强效诱导剂。 OA相关疼痛中的潜在作用？
2. TGF-beta is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain? [J] . Davidson E. N. Blaney, van Caam A. P. M., Vitters E. L., Osteoarthritis and cartilage . 2015,第3期

机译：TGF-β通过ALK5-Smad2 / 3途径是关节软骨中神经生长因子的有效诱导剂。在OA相关疼痛中的潜在作用？
3. TGF-beta IS A POTENT INDUCER OF NERVE GROWTH FACTOR IN ARTICULAR CARTILAGE VIA THE ALK5-SMAD2/3 PATHWAY. POTENTIAL ROLE IN OA RELATED PAIN? [J] . Davidson E. N. Blaney, van Caam A. P., Vitters E. L., Osteoarthritis and cartilage . 2015,第Suppla2期

机译：TGF-β是通过ALK5-SMAD2 / 3途径的关节软骨中神经生长因子的有效诱导剂。在OA相关疼痛中的潜在作用？
4. Articular cartilage tissue engineering with plasma-rich in growth factors and stem cells with Nano scaffolds [C] . Laila M. Montaser, Hadeer A. Abbassy, Sherin M. Fawzy Biosensing and nanomedicine IX . 2016

机译：血浆中生长因子和干细胞丰富的关节软骨组织工程与纳米支架
5. Role of Transient Receptor Potential Vanilloid 1 and Oxidation in a Rodent Model of Nerve Growth Factor-Induced Persistent Pain [D] . Eskander, Michael Andrew. 2019

机译：暂时性受体电位香草醛1和氧化在啮齿动物神经生长因子诱导的持续性疼痛模型中的作用。
6. Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics [O] . Venkatachalam Natarajan, Balaraman Madhan, Moti L. Tiku -1

机译：关节腔内注射多酚可保护关节软骨免于炎症引起的降解：提示其在软骨治疗中的潜在作用
7. TGF-β is a potent inducer of nerve growth factor in articular cartilage via the ALK5-Smad2/3 pathway. potential role in OA related pain? [O] . Davidson E.N. Blaney, van Caam A.P., Vitters E.L., 2015

机译：TGF-β通过ALK5-Smad2 / 3途径是关节软骨中神经生长因子的有效诱导剂。 OA相关疼痛的潜在作用？

TGF-beta is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

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