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首页> 外文期刊>Osteoarthritis and cartilage >Intra-articular injections of hyaluronan solutions of different elastoviscosity reduce nociceptive nerve activity in a model of osteoarthritic knee joint of the guinea pig.
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Intra-articular injections of hyaluronan solutions of different elastoviscosity reduce nociceptive nerve activity in a model of osteoarthritic knee joint of the guinea pig.

机译：在豚鼠骨关节炎膝关节模型中，关节腔内注射不同弹性粘度的透明质酸溶液可降低伤害性神经活动。

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OBJECTIVE: To study in guinea pigs knee joints the effects of intra-articular injection of HYADD 4-G (Fidia-Farmaceutici), a novel hyaluronan (HA)-derived elastoviscous material and of Hyalgan (Fidia-Farmaceutici), a HA product with very low viscoelasticity, on movement-evoked nociceptor impulse activity from normal and inflamed knee joints. DESIGN: Nociceptor impulse activity was recorded from single Adelta and C fibers of the medial articular nerve either under control conditions or after induction of an experimental knee joint osteoarthritis (OA) by partial medial menisectomy and transection of the anterior cruciate ligament (PMM-TACL). The stimuli consisted of standardized innocuous and noxious inward and outward rotations of the tibia against the femur of 50s duration, repeated every 5min for 1.5h. RESULTS: The number of movement-evoked impulses was significantly augmented 1 day and 1 week after PMM-TACL compared with intact knee joint. The enhanced impulse response to joint movements 1 week following surgery was attenuated by repeated intra-articular injection of HYADD 4-G and even more prominently by Hyalgan. CONCLUSIONS: HA products have a reducing action on joint nociceptor discharges that appears to depend predominantly on their role as an elastoviscous filter associated with their rheological properties, but also on a chemical effect on sensitized nociceptive terminals of inflamed joint tissues, possibly linked to the HA concentration.
机译：目的：研究豚鼠膝关节内注射透明质酸（HA）衍生的新型弹性粘连材料HYADD 4-G（Fidia-Farmaceutici）和含有HA的产品Hyalgan（Fidia-Farmaceutici）的关节腔注射效果由于正常和发炎的膝关节引起的运动诱发伤害感受器脉冲活动，粘弹性非常低。设计：在控制条件下或通过部分内侧半月板切除术和前交叉韧带横断术（PMM-TACL）诱发实验性膝关节骨关节炎（OA）后，从内侧关节神经的单个Adelta和C纤维记录了伤害感受器脉冲活动。刺激包括标准的无痛和有毒的胫骨向内和向外旋转，持续50s的股骨，每5分钟重复1.5h。结果：与完整的膝关节相比，PMM-TACL术后1天和1周运动诱发的搏动次数显着增加。重复关节内注射HYADD 4-G可以减轻术后1周对关节运动的增强冲动反应，而Hyalgan则更为明显。结论：HA产品对关节伤害感受器放电具有还原作用，这似乎主要取决于其作为具有流变学性质的弹性粘膜过滤器的作用，还取决于对发炎的关节组织敏化伤害感受性末端的化学作用，可能与HA浓度。

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