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首页> 外文期刊>Osteoarthritis and cartilage >Growth-factor-induced healing of partial-thickness defects in adult articular cartilage.
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Growth-factor-induced healing of partial-thickness defects in adult articular cartilage.

机译：生长因子诱导的成人关节软骨部分厚度缺陷的愈​​合。

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OBJECTIVE: We have previously shown (Hunziker and Rosenberg, J Bone Joint Surg 1996;78A:721-33) that synovial cells can be induced to migrate into partial-thickness articular cartilage defects, therein to proliferate and subsequently to deposit a scar-like tissue. We now wished to ascertain whether these synovial cells could be stimulated to transform into chondrocytes, and thus to lay down cartilage tissue, by the timely introduction of a differentiation factor. DESIGN: Partial-thickness defects were created in the knee-joint cartilage of adult miniature pigs. These were then filled with a fibrin matrix containing a free chemotactic/mitogenic factor and a liposome-encapsulated chondrogenic differentiation one. Tissue was analyzed (immuno)histochemically at 2, 6 and 12 months. RESULTS: Defects became filled with cartilage-like tissue which registered positive for all major cartilage-matrix components; it remained compositionally stable throughout the entire follow-up period. CONCLUSION: Although still requiring considerable refinement, our one-step, growth-factor-based treatment strategy has the basic potential to promote intrinsic healing of partial-thickness articular cartilage defects, thus obviating the need for transplanting cells or tissue.
机译：目的：我们先前已经证明（Hunziker and Rosenberg，J Bone Joint Surg 1996; 78A：721-33），滑膜细胞可以被诱导迁移到部分厚度的关节软骨缺损中，在其中扩散并随后沉积成疤痕样组织。我们现在希望确定是否可以通过及时引入分化因子来刺激这些滑膜细胞转化为软骨细胞，从而沉积软骨组织。设计：成年小型猪的膝关节软骨中产生了部分厚度的缺陷。然后用纤维蛋白基质填充其中，所述纤维蛋白基质包含游离趋化/促有丝分裂因子和脂质体包囊的成软骨分化细胞。在第2、6和12个月时对组织进行分析（免疫）组织化学分析。结果：缺损处充满了软骨样组织，所有主要软骨基质成分均呈阳性。在整个随访期间，其成分保持稳定。结论：尽管仍需进行大量改进，但我们的基于生长因子的一步治疗策略具有促进局部增厚的关节软骨缺损的内在愈合的基本潜力，因此无需移植细胞或组织。

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