Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation.

Derfus BA; Camacho NP; Olmez U; Kushnaryov VM; Westfall PR; Ryan LM; Rosenthal AK

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Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation.

机译：转化生长因子β-1刺激能够增加焦磷酸钙沉淀的基质小泡对关节软骨的形成。

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Objective To determine the role of transforming growth factor beta1 (TGFbeta) in early calcium pyrophosphate formation by measuring its effects on articular chondrocyte matrix vesicle (MV) formation, specific activity of the inorganic pyrophosphate(PPi)-generating enzyme nucleoside triphosphate pyrophospho-hydrolase (NTPPPH) and biomineralization capacity.Methods MV elaborated from mature porcine chondrocyte monolayers+/-TGFbeta were compared for protein content, NTPPPH activity, and ATP-dependent biomineralization. Precipitation of calcium pyrophosphate mineral phases by MV was determined by a radiometric assay and by Fourier transform infrared spectroscopy (FTIR).Results MV from monolayers exposed to TGFbeta were enriched in NTPPPH activity compared to MV from control monolayers (P< 0.01) and precipitated more calcium/mg MV protein than controls (P

机译：目的通过测量其对关节软骨细胞基质囊泡（MV）的形成，产生无机焦磷酸盐（PPi）的酶核苷三磷酸焦磷酸水解酶（比活性）的影响，确定转化生长因子β1（TGFbeta）在焦磷酸钙早期形成中的作用。方法比较了成熟猪软骨细胞单层+/- TGFbeta制备的MV的蛋白质含量，NTPPPH活性和ATP依赖性生物矿化。 MV测定了焦磷酸钙矿相的放射性测定和傅里叶变换红外光谱（FTIR）。结果与对照单层的MV相比，暴露于TGFbeta的单层的MV富含NTPPPH活性（P <0.01），并且沉淀更多钙/毫克MV蛋白比对照组高（P

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《Osteoarthritis and cartilage》 |2001年第3期|共6页
作者
Derfus BA; Camacho NP; Olmez U; Kushnaryov VM; Westfall PR; Ryan LM; Rosenthal AK;
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正文语种 eng
中图分类外科学;
关键词
Calcium Pyrophosphate; Chondrocytes; Pyrophosphatases; Transforming Growth Factor beta; 焦磷酸钙; 软骨细胞; 焦磷酸酶类; 转化生长因子β;

机译：Calcium Pyrophosphate;Chondrocytes;Pyrophosphatases;Transforming Growth Factor beta;焦磷酸钙;软骨细胞;焦磷酸酶类;转化生长因子β;

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1. Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. [J] . Derfus BA, Camacho NP, Olmez U, Osteoarthritis and cartilage . 2001,第3期

机译：转化生长因子β-1刺激能够增加焦磷酸钙沉淀的基质小泡对关节软骨的形成。
2. Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. [J] . Derfus BA, Camacho NP, Olmez U, Osteoarthritis and cartilage . 2001,第3期

机译：转化生长因子β-1刺激能够增加焦磷酸钙沉淀的基质小泡对关节软骨的形成。
3. Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte [J] . Frederic Cailotto, Pascal Reboul, Sylvie Sebillaud, The Journal of biological chemistry . 2011,第22期

机译：钙输入增强了转化生长因子（TGF）-β1依赖性信号传导，以促进眼镜软骨细胞的无机焦磷酸盐的出口
4. Matrix Vesicles Contain Metalloproteinases that Are Released into the Matrix by Treatment with 1alpha,25(OH)_2D_3 and Are Capable of Activating Latent Transforming Growth Factor-betal [C] . David D. Dean, Shingo Maeda, Zvi Schwartz, Falk Symposium . 2002

机译：基质囊泡含有金属蛋白酶通过用1Alpha，25（OH）_2D_3处理并能够激活潜伏的转化生长因子 - BETAL释放到基质中
5. STUDIES ON THE MECHANISM OF MATRIX VESICLE FORMATION BY CULTURED EPIPHYSEAL GROWTH PLATE CHONDROCYTES. [D] . HALE, JOHN EDWARD. 1986

机译：培养的表皮生长板软骨细胞对基质囊形成机理的研究。
6. Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte [O] . Frederic Cailotto, Pascal Reboul, Sylvie Sebillaud, 2011

机译：钙输入增强了转化生长因子（TGF）-β1依赖性信号以促进关节软骨细胞输出无机焦磷酸。
7. Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation [O] . Derfus B.A., Camacho N.P., Olmez U., 2001

机译：转化生长因子β-1刺激能够增加焦磷酸钙沉淀的基质囊泡的软骨细胞形成

Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation.

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