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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig

机译：OARSI组织病理学计划-对豚鼠骨关节炎的组织学评估建议

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Objective: This review focuses on the criteria for assessing osteoarthritis (OA) in the guinea pig at the macroscopic and microscopic levels, and recommends particular assessment criteria to assist standardization in the conduct and reporting of preclinical trails in guinea pig models of OA. Methods: A review was conducted of all OA studies from 1958 until the present that utilized the guinea pig. The PubMed database was originally searched August 1, 2006 using the following search terms: guinea pig and OA. We continued to check the database periodically throughout the process of preparing this chapter and the final search was conducted January 7, 2009. Additional studies were found in a review of abstracts from the OsteoArthritis Research Society International (OARSI) conferences, Orthopaedic Research Society (ORS) conferences, and literature related to histology in other preclinical models of OA reviewed for relevant references. Studies that described or used systems for guinea pig joint scoring on a macroscopic, microscopic, or ultrastructural basis were included in the final comprehensive summary and review. General recommendations regarding methods of OA assessment in the guinea pig were derived on the basis of a comparison across studies and an inter-rater reliability assessment of the recommended scoring system.Results: A histochemical-histological scoring system (based on one first introduced by H. Mankin) is recommended for semi-quantitative histological assessment of OA in the guinea pig, due to its already widespread adoption, ease of use, similarity to scoring systems used for OA in humans, its achievable high inter-rater reliability, and its demonstrated correlation with synovial fluid biomarker concentrations. Specific recommendations are also provided for histological scoring of synovitis and scoring of macroscopic lesions of OA.Conclusions: As summarized herein, a wealth of tools exist to aid both in the semi-quantitative and quantitative assessme...
机译：目的：本综述着眼于在宏观和微观水平上评估豚鼠骨关节炎（OA）的标准，并建议特殊的评估标准，以协助标准化和报告豚鼠OA模型的临床前试验。方法：回顾了从1958年到现在使用豚鼠的所有OA研究。 PubMed数据库最初是在2006年8月1日使用以下搜索词进行搜索的：豚鼠和OA。在准备本章的整个过程中，我们继续定期检查数据库，最终搜索于2009年1月7日进行。在对国际骨关节炎研究学会（OARSI）会议，骨科研究学会（ORS）的摘要的审查中发现了其他研究。 ）会议以及与OA的其他临床前模型有关的组织学文献进行了综述，以供参考。最终综合摘要和综述中包括描述或使用宏观，微观或超微结构对豚鼠关节评分系统的研究。关于豚鼠骨关节炎评估方法的一般建议是根据研究比较和推荐评分系统的评估者间可靠性评估得出的。结果：组织化学-组织学评分系统（基于H首次提出的一种） （Mankin）被推荐用于豚鼠OA的半定量组织学评估，因为它已被广泛采用，易于使用，与人类OA评分系统相似，其可实现的高评估者间可靠性和已被证明与滑液生物标志物浓度的相关性。还提供了针对滑膜炎的组织学评分和OA宏观病变评分的具体建议。结论：如本文所述，存在大量辅助半定量和定量评估的工具...

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