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首页> 外文期刊>Osteoarthritis and cartilage >Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis.
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Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis.

机译：强化减肥计划对肥胖成人膝骨关节炎患者膝关节负荷的影响。

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OBJECTIVE: To determine the effect of an intensive weight loss program on knee joint loads during walking in obese patients with knee osteoarthritis (OA). METHODS: Participants included 157 obese knee OA patients that underwent a 16-week dietary intervention. Three-dimensional gait analyses were performed before and after the intervention at the participants' freely chosen walking speed. Knee joint compression forces, axial impulses, knee flexion angle and frontal and sagittal plane knee moments were calculated to determine the biomechanical effects of the weight loss. RESULTS: 157 subjects (89% of the initial cohort) completed the 16-week intervention. The average weight loss of 13.7kg (P<.0001) corresponded to 13.5% of the baseline body weight. The weight loss resulted in a 7% reduction in knee joint loading, a 13% lower axial impulse, and a 12% reduction in the internal knee abductor moment (KAM). There were no clear effects on sagittal plane knee moments or peak knee flexion angle. Linear regression analyses adjusted for changes in walking speed showed that for every 1kg in weight loss, the peak knee load was reduced by 2.2kg. Thus, every kilo reduction in body weight was related to more than twice the reduction in peak knee force at a given walking speed. CONCLUSION: Weight loss is an excellent short-term investment in terms of joint loading for patients with combined obesity and knee OA. The effects of sustained weight loss on disease progression and symptoms in relation to biomechanical factors remain to be shown.
机译：目的：确定肥胖的膝关节骨关节炎（OA）患者在步行过程中强化减肥计划对膝关节负荷的影响。方法：参与者包括157名接受16周饮食干预的肥胖膝盖OA患者。在干预之前和之后，以参与者自由选择的步行速度进行三维步态分析。计算膝关节的压缩力，轴向脉冲，膝盖的弯曲角度以及额面和矢状面的膝盖力矩，以确定体重减轻的生物力学影响。结果：157名受试者（占初始队列的89％）完成了16周的干预。平均体重减轻13.7kg（P <.0001），相当于基线体重的13.5％。体重减轻导致膝关节负荷降低7％，轴向脉冲降低13％，内部膝关节外展力矩（KAM）降低12％。对矢状面膝关节力矩或最大屈膝角度没有明显影响。根据步行速度的变化进行线性回归分析后发现，每减轻1千克体重，膝盖的峰值负重就会减少2.2千克。因此，在给定的步行速度下，每公斤体重的减少与峰值膝盖力的减少的两倍以上有关。结论：对于合并肥胖和膝骨关节炎的患者，就关节负荷而言，减肥是一项极好的短期投资。持续减肥对疾病进展和与生物力学因素相关的症状的影响仍有待显示。

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