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首页> 外文期刊>Osteoarthritis and cartilage >Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review.
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Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review.

机译：膝关节骨关节炎对放射线关节间隙宽度变化的响应和测量的可靠性：系统评价。

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OBJECTIVE: The goal of this systematic review was to report the responsiveness to change and reliability of conventional radiographic joint space width (JSW) measurement. METHOD: We searched the PubMed and Embase databases using the following search criteria: [osteoarthritis (OA) (MeSH)] AND (knee) AND (X-ray OR radiography OR diagnostic imaging OR radiology OR disease progression) AND (joint space OR JSW or disease progression). We assessed responsiveness by calculating the standardized response mean (SRM). We assessed reliability using intra- and inter-reader intra-class correlation (ICC) and coefficient of variation (CV). Random-effects models were used to pool results from multiple studies. Results were stratified by study duration, design, techniques of obtaining radiographs, and measurement method. RESULTS: We identified 998 articles using the search terms. Of these, 32 articles (43 estimates) reported data on responsiveness of JSW measurement and 24 (50 estimates) articles reported data on measures of reliability. The overall pooled SRM was 0.33 [95% confidence interval (CI): 0.26, 0.41]. Responsiveness of change in JSW measurement was improved substantially in studies of greater than 2 years duration (0.57). Further stratifying this result in studies of greater than 2 years duration, radiographs obtained with the knee in a flexed position yielded an SRM of 0.71. Pooled intra-reader ICC was estimated at 0.97 (95% CI: 0.92, 1.00) and the intra-reader CV estimated at 3.0 (95% CI: 2.0, 4.0). Pooled inter-reader ICC was estimated at 0.93 (95% CI: 0.86, 0.99) and the inter-reader CV estimated at 3.4% (95% CI: 1.3%, 5.5%). CONCLUSIONS: Measurement of JSW obtained from radiographs in persons with knee is reliable. These data will be useful to clinicians who are planning RCTs where the change in minimum JSW is the outcome of interest.
机译：目的：本系统综述的目的是报告传统放射照相关节间隙宽度（JSW）测量对变化的响应和可靠性。方法：我们使用以下搜索标准搜索PubMed和Embase数据库：[骨关节炎（OA）（MeSH）]和（膝盖）和（X射线或X射线摄影或诊断成像或放射学或疾病进展）和（关节腔或JSW或疾病进展）。我们通过计算标准化反应平均值（SRM）评估了反应能力。我们使用阅读器内和阅读器内类间相关性（ICC）和变异系数（CV）评估了可靠性。随机效应模型用于汇总多项研究的结果。结果按研究时间，设计，射线照相技术和测量方法进行分层。结果：我们使用搜索词找到了998条文章。其中，有32篇文章（43个估计值）报告了有关JSW测量响应性的数据，有24篇文章（50个估计值）报告了有关可靠性度量的数据。总合并SRM为0.33 [95％置信区间（CI）：0.26、0.41]。在持续时间超过2年的研究中，JSW测量变化的响应能力得到了显着改善（0.57）。在持续时间超过2年的研究中，该结果进一步分层，膝盖处于屈曲位置时获得的X射线照片得出SRM为0.71。阅读器内合并ICC估计为0.97（95％CI：0.92，1.00），阅读器内CV估计为3.0（95％CI：2.0，4.0）。阅读器之间的合并ICC估计为0.93（95％CI：0.86，0.99），阅读器间CV估计为3.4％（95％CI：1.3％，5.5％）。结论：从膝关节X线片获得的JSW的测量是可靠的。这些数据对正在计划进行RCT的临床医生很有用，其中最小JSW的变化是令人感兴趣的结果。

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