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首页> 外文期刊>Osteoarthritis and cartilage >Cartilage repair of the ankle: First results of T2 mapping at 7.0 T after microfracture and matrix associated autologous cartilage transplantation
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Cartilage repair of the ankle: First results of T2 mapping at 7.0 T after microfracture and matrix associated autologous cartilage transplantation

机译：踝关节软骨修复：微骨折和基质相关自体软骨移植后7.0 T T2定位的初步结果

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Background: Both microfracture (MFX) and matrix associated autologous cartilage transplantation (MACT) are currently used to treat cartilage defects of the talus. T2 mapping of the ankle at 7 T has the potential to assess the collagen fibril network organization of the native hyaline cartilage and of the repair tissue (RT). This study provides first results regarding the properties of cartilage RT after MFX (mean follow-up: 113.8 months) and MACT (65.4 months). Methods: A multi-echo spin-echo sequence was used at 7 T to assess T2 maps in 10 volunteer cases, and in 10 cases after MFX and MACT each. Proton weighted morphological images and clinical data were used to ensure comparable baseline criteria. Results: A significant zonal variation of T2 was found in the volunteers. T2 of the superficial and the deep layer was 39.3 ± 5.9 ms and 21.1 ± 3.1 ms (zonal T2 index calculated by superficial T2/deep T2: 1.87 ± 0.2, P < 0.001). In MFX, T2 of the reference cartilage was 37.4 ± 5.0 ms and 25.3 ± 3.5 ms (1.51 ± 0.3, P < 0.001). In the RT, T2 was 43.4 ± 10.5 ms and 36.3 ± 7.7 ms (1.20 ± 0.2, P = 0.009). In MACT, T2 of the reference cartilage was 39.0 ± 9.1 ms and 27.1 ± 6.6 ms (1.45 ± 0.2, P < 0.001). In the RT, T2 was 44.6 ± 10.4 ms and 38.6 ± 7.3 ms (1.15 ± 0.1, P = 0.003). The zonal RT T2 variation differed significantly from the reference cartilage in both techniques (MFX: P = 0.004, MACT: P = 0.001). Conclusion: T2 mapping at 7 T allows for the quantitative assessment of the collagen network organization of the talus. MACT and MFX yielded RT with comparable T2 properties.
机译：背景：微骨折（MFX）和基质相关的自体软骨移植（MACT）目前都用于治疗距骨的软骨缺损。踝关节在T 2 T处的T2定位有可能评估天然透明软骨和修复组织（RT）的胶原纤维网络组织。这项研究提供了有关MFX（平均随访：113.8个月）和MACT（65.4个月）后软骨RT特性的初步结果。方法：采用多回波自旋回波序列于7 T评估10例志愿者病例以及MFX和MACT术后10例患者的T2图谱。使用质子加权形态图像和临床数据来确保可比较的基线标准。结果：在志愿者中发现了T2的显着区域性变化。浅层和深层的T2为39.3±5.9 ms和21.1±3.1 ms（通过浅层T2 /深T2计算的区域T2指数：1.87±0.2，P <0.001）。在MFX中，参考软骨的T2为37.4±5.0毫秒和25.3±3.5毫秒（1.51±0.3，P <0.001）。在RT中，T2为43.4±10.5 ms和36.3±7.7 ms（1.20±0.2，P = 0.009）。在MACT中，参考软骨的T2为39.0±9.1 ms和27.1±6.6 ms（1.45±0.2，P <0.001）。在RT中，T2为44.6±10.4 ms和38.6±7.3 ms（1.15±0.1，P = 0.003）。在两种技术中，区域RT T2的变化均与参考软骨有显着差异（MFX：P = 0.004，MACT：P = 0.001）。结论：T2在7 T定位可以定量评估距骨的胶原网络组织。 MACT和MFX产生的RT具有可比的T2特性。

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