...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Osteoarthritis and cartilage >Matrix-associated autologous chondrocyte transplantation in a compartmentalized early stage of osteoarthritis
【24h】

Matrix-associated autologous chondrocyte transplantation in a compartmentalized early stage of osteoarthritis

机译：骨关节炎早期分隔的基质相关自体软骨细胞移植

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Cartilage restoration in joints with an early stage of osteoarthritis (OA) is an important clinical challenge. In this study, a compartmentalized, early-stage OA was generated surgically in sheep stifle joints, and this model was used to evaluate a matrix-associated cell transplantation approach for cartilage repair. Method: Eighteen sheep were operated twice. During the first operation, a unicompartmental OA in a stable joint was induced by creating a critical-size defect. The second operation served as a regeneration procedure. The eighteen sheep were divided into three groups. One group was treated with spongialization (SPONGIO), while the two others had spongialization followed by implantation of a hyaluronan matrix with (MACT) or without chondrocytes (MATRIX). The follow-up took place 4 months after the second operation. Gross Assessment of Joint Changes score and Brittberg score were used for the macroscopic evaluation, Mankin score, O'Driscoll score, and immunohistochemistry for collagen type I and type II for histological evaluation. Results: The MACT group achieved significantly better results in both macroscopic and histological examinations. In the regeneration area, a Mankin score of 7.88 (6.20; 9.55) [mean (upper 95% confidence interval; lower 95% confidence interval)] was reached in the MACT group, 10.38 (8.03; 12.72) in the MATRIX group, and 10.33 (8.80; 11.87) in the SPONGIO group. The O'Driscoll score revealed a highly significant difference in the degree of defect repair: 15.92 (14.58; 17.25) for the MACT group compared to the two other groups [5.04 (1.21; 8.87) MATRIX and 6.58 (5.17; 8.00) SPONGIO; P < 0.0001]. Conclusion: This study demonstrates promising results toward the development of a biological regeneration technique for early-stage OA.
机译：目的：早期骨关节炎（OA）的关节软骨修复是一项重要的临床挑战。在这项研究中，通过手术在绵羊的窒息关节中产生了一个间隔期的早期OA，该模型用于评估基质相关的细胞移植方法来修复软骨。方法：对18只绵羊进行两次手术。在第一次手术中，通过产生临界大小的缺损，在稳定的关节中诱发了单室骨关节炎。第二操作用作再生程序。十八只羊分为三组。一组进行了海绵化治疗（SPONGIO），而其他两组进行了海绵化治疗，然后植入了透明质酸基质，其中加入了（MACT）或不加入软骨细胞（MATRIX）。在第二次手术后四个月进行了随访。大体评估关节变化评分和Brittberg评分用于宏观评估，Mankin评分，O'Driscoll评分以及I型和II型胶原的免疫组织化学用于组织学评估。结果：MACT组在肉眼和组织学检查中均取得了明显更好的结果。在再生区域中，MACT组的Mankin评分为7.88（6.20; 9.55）[平均值（95％置信区间上限; 95％的置信区间下限）]，MATRIX组的Mankin评分为10.38（8.03; 12.72）。 SPONGIO组中的10.33（8.80; 11.87）。 O'Driscoll评分显示出缺陷修复程度的显着差异：MACT组为15.92（14.58; 17.25），而其他两组为[5.04（1.21; 8.87）MATRIX和6.58（5.17; 8.00）SPONGIO; P <0.0001]。结论：这项研究证明了早期OA的生物再生技术的发展前景可观。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号