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首页> 外文期刊>Osteoarthritis and cartilage >Muscle weakness causes joint degeneration in rabbits.
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Muscle weakness causes joint degeneration in rabbits.

机译：肌肉无力导致兔子关节变性。

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OBJECTIVE: The objective of this study was to investigate the effects of botulinum toxin type-A (BTX-A) induced quadriceps weakness on micro-structural changes in knee cartilage of New Zealand White (NZW) rabbits. DESIGN: Fifteen rabbits were divided randomly into an experimental and a sham control group. Each group received a unilateral single quadriceps muscle injection either with saline (sham control; n=4) or BTX-A (experimental; n=11). RESULTS: BTX-A injection produced significant quadriceps muscle weakness (P<0.05) and loss of quadriceps muscle mass (P<0.05). Degenerative changes of the knee cartilage, assessed with the Mankin grading system, were the same for the injected and non-injected hind limbs of the experimental group animals. Sham injection had no effect on joint degeneration but all control animals showed some degenerative changes in the knee. Degenerative changes of the retro-patellar cartilage were more severe in the experimental compared to sham control group rabbits (P<0.05). The distal region of the retro-patellar cartilage was more degenerated than the proximal part in the experimental and control group rabbits (P<0.05). The Mankin grades for the tibiofemoral region were not significantly different between experimental and control group rabbits (P>0.05). CONCLUSION: Quadriceps muscle weakness caused increased degeneration in the retro-patellar cartilage of NZW rabbits, providing evidence that muscle weakness might be a risk factor for the onset and progression of osteoarthritis (OA). Future work needs to delineate whether muscle weakness directly affects joint degeneration, or if changes in function and movement execution associated with muscle weakness are responsible for the increased rate of OA onset and progression observed here.
机译：目的：研究A型肉毒杆菌毒素（BTX-A）诱发的股四头肌无力对新西兰白（NZW）兔膝软骨微结构变化的影响。设计：将15只兔随机分为实验组和假对照组。每组接受单侧股四头肌肌肉注射盐水（假手术对照组; n = 4）或BTX-A（实验组; n = 11）。结果：BTX-A注射液使股四头肌明显无力（P <0.05），股四头肌质量下降（P <0.05）。用Mankin分级系统评估的膝软骨的退行性变化对于实验组动物的注射后和未注射后肢是相同的。假注射对关节退变没有影响，但是所有对照动物的膝盖均出现了一些退行性改变。与假对照组相比，实验中-骨后软骨的退行性变更为严重（P <0.05）。实验组和对照组兔的the骨后软骨远侧区较近侧区更退化（P <0.05）。实验组和对照组兔的胫股区域的Mankin等级没有显着差异（P> 0.05）。结论：股四头肌肌无力导致NZW兔-骨后软骨变性增加，提供了证据表明肌无力可能是骨关节炎（OA）发作和发展的危险因素。未来的工作需要确定肌肉无力是否直接影响关节退化，或者与肌肉无力相关的功能和运动执行变化是否是导致此处观察到的OA发病率和进展率增加的原因。

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