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One small step in the right direction for MRI measurement performance.

机译：朝着正确方向进行MRI测量性能的一小步。

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Extensive efforts are currently underway to understand the earliest pathologic changes in synovial joint tissues. These efforts are motivated in part by a desire to understand the pathophysiologic alterations that occur in diseases of the joint. However, in large part the efforts are promoted by the necessity to develop agents to modify structural changes that occur with disease, and the parallel requirement that we have imaging methods to measure these structural changes that are valid, responsive and clinically relevant. Historically we have relied upon plain radiography to depict disease severity in osteoarthritis (OA) and to ascertain progression by determining changes in joint space. With the acknowledged limitations of these methods, development of methods to directly visualize and measure joint tissues including magnetic resonance imaging (MRI) have been pursued1. Much of this focus has been on measurement of articular cartilage morphometry. Measurement of morphometry appears to correlate well with the ex vivo assessments of cartilage volume (stripped away from bone), in addition to possessing adequate precision and sensitivity to change . Recent MRI studies, however, have observed small rates of change (-1-3% loss per year) and standardized response means of -0.3-0.5 per year. Possibly more importantly these measures of quantitative cartilage morphometry appear most useful (sensitive to change) in persons with late stage disease (such as in those with established JSN or extensive areas of denuded cartilage)9. If the pathological changes of cartilage loss are irreversible, and we focus especially on those at the end stage of the disease, we may not be able to accomplish our goal of modifying the progress of the condition as a drug may not produce cartilage in an already denuded area.
机译：目前正在进行广泛的努力以了解滑膜关节组织的最早病理变化。这些努力的部分动机是希望了解关节疾病中发生的病理生理变化。但是，很大一部分努力是由于必须开发能改变疾病发生的结构变化的药物，以及对并行的要求，即我们必须有成像方法来测量这些结构变化，这些结构变化是有效的，反应迅速的并且与临床相关的。从历史上看，我们依靠放射线照相来描绘骨关节炎（OA）中的疾病严重程度，并通过确定关节间隙的变化来确定病情进展。由于这些方法的局限性，已经进行了直接可视化和测量关节组织的方法的开发，包括磁共振成像（MRI）1。这些重点大多集中在关节软骨形态的测量上。除了具有足够的精度和变化敏感性外，形态计量学的测量似乎与软骨体积的体外评估（从骨头上剥离）有很好的相关性。然而，最近的MRI研究发现变化率很小（每年损失1-3％），标准化响应方式每年为-0.3-0.5。可能更重要的是，这些定量软骨形态测量指标在患有晚期疾病的人（例如那些已建立JSN或广泛的软骨剥脱区域的人）中似乎最有用（对变化敏感）9。如果软骨丧失的病理变化是不可逆的，并且我们特别关注于疾病的晚期阶段，那么我们可能无法实现改变病情进展的目标，因为药物可能已经不产生软骨了。裸露区域。

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