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Histopathology atlas of animal model systems - overview of guiding principles

机译：动物模型系统的组织病理学图集-指导原则概述

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Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the development of therapeutic agents and biological markers for diagnosing and prognosing the disease. Thus, it is of great importance for the OA scientific community, both in academic as well as industrial research, to standardize scoring systems for evaluating the OA disease process and to make results between different studies comparable. The task of the histopathology initiative of OARSI was to achieve a consensus of scoring systems for the most important species used in OA animal model research (dog, guinea pig, horse, mouse, rabbit, rat, and sheep/goat), which are presented in the various chapters in this special volume of Osteoarthritis & Cartilage together with extra chapters on basic methodology (histochemistry, statistics, morphometry), the specific terminology and a general discussion of animal models in OA research. Standardized definitions are suggested for basic but essential terms such as "grading" and "staging" in order to promote their consistent use and thereby promote improved understanding and data interpretation across all model systems. Thus, this introductory chapter presents an overview of the guiding principles for assessment of important OA animal model systems. Use of such systems, independently or in conjunction with other systems in parallel, should facilitate comparability of results across animal model studies.
机译：动物模型系统代表了人类骨关节炎（OA）研究的重要辅助和替代。它们提供了一种研究OA病理生理的手段，并有助于开发用于诊断和预后疾病的治疗剂和生物标记物。因此，对于OA科学界，无论是在学术研究还是工业研究中，标准化评估OA疾病过程的评分系统并使不同研究之间的结果具有可比性都非常重要。 OARSI的组织病理学计划的任务是就OA动物模型研究中使用的最重要物种（狗，豚鼠，马，小鼠，兔，大鼠和绵羊/山羊）的评分系统达成共识。在这本《骨关节炎和软骨》专刊中的各个章节中，以及有关基本方法（组织化学，统计学，形态计量学），特定术语以及OA研究中的动物模型的一般性讨论的其他章节。建议对基本但必不可少的术语（例如“等级”和“阶段”）使用标准化的定义，以促进它们的一致使用，从而促进所有模型系统之间更好的理解和数据解释。因此，本介绍性章节概述了评估重要OA动物模型系统的指导原则。单独或与其他平行的系统结合使用这些系统，应可促进动物模型研究结果的可比性。

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