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首页> 外文期刊>Osteoarthritis and cartilage >A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging--data from the Osteoarthritis Initiative.
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A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging--data from the Osteoarthritis Initiative.

机译：一种用于MR成像T2测量的新型快速膝关节软骨分割技术-来自骨关节炎计划的数据。

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摘要

Magnetic resonance imaging (MRI) T(2) relaxation time assesses non-invasively cartilage composition and can be used as early biomarker for knee osteoarthritis. Most knee cartilage segmentation techniques were primarily developed for volume measurements in DESS or SPGR sequences. For T(2) quantifications, these segmentations need to be superimposed on T(2) maps. However, given that these procedures are time consuming and require manual alignment, using them for analysis of T(2) maps in large clinical trials like the Osteoarthritis Initiative (OAI) is challenging. A novel direct segmentation technique (DST) for T(2) maps was therefore developed. Using the DST, T(2) measurements were performed and compared with those determined with an established segmentation superimposition technique (SST). MR images of five OAI participants were analysed with both techniques three times by one reader and five different images sets additionally with DST three times by two readers. Segmentations and T(2) measurements of one knee required on average 63+/-3min with DST (vs 302+/-13min for volume and T(2) measurements with SST). Bland-Altman plots indicated good agreement between the two segmentation techniques, respectively the two readers. Reproducibility errors of both techniques (DST vs SST) were similar (P>0.05) for whole knee cartilage mean T(2) (1.46% vs 2.18%), laminar (up to 2.53% vs 3.19%) and texture analysis (up to 8.34% vs 9.45%). Inter-reader reproducibility errors of DST were higher for texture analysis (up to 15.59%) than for mean T(2) (1.57%) and laminar analysis (up to 2.17%). Due to these results, the novel DST can be recommended for T(2) measurements in large clinical trials like the OAI.
机译：磁共振成像（MRI）T（2）弛豫时间评估了非侵入性软骨的成分，可以用作膝盖骨关节炎的早期生物标记。大多数膝关节软骨分割技术主要是针对DESS或SPGR序列的体积测量而开发的。对于T（2）量化，这些分段需要叠加在T（2）映射上。但是，由于这些过程很耗时且需要手动对齐，因此在像骨关节炎倡议（OAI）这样的大型临床试验中使用它们来分析T（2）图非常具有挑战性。因此，开发了一种新颖的T（2）地图直接分割技术（DST）。使用DST，进行了T（2）测量，并与已建立的分段叠加技术（SST）确定的测量结果进行了比较。一位读者用这两种技术对五名OAI参与者的MR图像进行了三遍分析，另外两位读者对DST的五种不同图像集进行了三遍分析。使用DST平均需要63 +/- 3min进行一个膝盖的分割和T（2）测量（相比之下，使用SST进行体积和T（2）测量平均需要302 +/- 13min）。布兰德-奥特曼（Bland-Altman）图显示了两种分割技术（分别是两种读者）之间的良好一致性。两种技术（DST与SST）的重现性误差在全膝关节平均T（2）（1.46％对2.18％），层流（高达2.53％对3.19％）和质地分析（对8.34％和9.45％）。 DST的读者间再现性误差在纹理分析（高达15.59％）方面高于平均T（2）（1.57％）和层流分析（在2.17％范围内）。由于这些结果，可以在诸如OAI的大型临床试验中推荐将新型DST用于T（2）测量。

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