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首页> 外文期刊>Osteoarthritis and cartilage >Cartilage boundary lubricating ability of aldehyde modified proteoglycan 4 (PRG4-CHO)
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Cartilage boundary lubricating ability of aldehyde modified proteoglycan 4 (PRG4-CHO)

机译：醛修饰蛋白聚糖4（PRG4-CHO）的软骨边界润滑能力

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摘要

Proteoglycan 4 (PRG4), also known as lubricin and superficial zone protein, is a mucinous glycoprotein that is present in synovial fluid (SF) and at the surface of articular cartilage, where it functions as a critical boundary lubricant necessary for joint health. High friction and high wear are amongst many factors that may contribute to cartilage degeneration. PRG4 is critical in reducing friction and minimising surface tissue shear at the surface of cartilage, thus preventing the degradation of cartilage through boundary lubrication. Indeed, an increased coefficient of friction in PRG4-knockout mice is associated with increased wear of the articular surface. Furthermore, intra-articular injection of PRG4 has been shown to prevent cartilage degradation in post-injury rat models of osteoarthritis (OA). A recent study, motivated by diminished PRG4 levels in SF associated with early OA, demonstrated aldehyde modification of PRG4 (PRG4-CH0) significantly enhanced its binding to a depleted articular surface
机译：蛋白聚糖4（PRG4）也称为润滑蛋白和浅表带蛋白，是一种滑液（SF）和关节软骨表面中存在的粘蛋白糖蛋白，在这里它是关节健康必不可少的重要边界润滑剂。高摩擦和高磨损是可能导致软骨变性的许多因素之一。 PRG4对于减少摩擦并最大程度地减少软骨表面的表面组织剪切，从而防止由于边界润滑引起的软骨退化至关重要。实际上，PRG4基因敲除小鼠的摩擦系数增加与关节表面的磨损增加有关。此外，在骨关节炎（OA）的大鼠损伤后模型中，已显示关节内注射PRG4可防止软骨降解。最近一项研究是由于与早期OA相关的SF中PRG4含量降低而引起的，表明PRG4（PRG4-CH0）的醛基修饰显着增强了其与衰竭关节表面的结合

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