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首页> 外文期刊>Osteoarthritis and cartilage >Physical activity, alignment and knee osteoarthritis: Data from MOST and the OAI
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Physical activity, alignment and knee osteoarthritis: Data from MOST and the OAI

机译：体力活动，对准和膝盖骨关节炎：来自MOST和OAI的数据

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Objective: To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment. Design: We combined data from Multicenter Osteoarthritis (MOST) and Osteoarthritis Initiative (OAI), studies of persons with or at high risk of OA. Subjects had long limb and repeated posteroanterior knee radiographs and completed the physical activity survey for the elderly (PASE). We studied persons without radiographic OA and excluded knees with major injury and without long limb films. We followed subjects 30 months (in MOST) and 48 months (in OAI) for one of two incident outcomes: (1) symptomatic tibiofemoral OA (radiographic OA and knee pain), or (2) tibiofemoral narrowing. 'Active' persons were those with PASE score in the highest quartile by gender. We examined risk of OA in active group using logistic regression adjusting for age, gender, body mass index (BMI), Western Ontario and McMaster Arthritis Index (WOMAC) pain score, Kellgren and Lawrence (KL) grade (0 or 1), and study of origin. We also analyzed knees from malaligned and neutrally aligned limbs. Results: The combined sample comprised 2,073 subjects (3,542 knees) with mean age 61 years. The cumulative incidence of symptomatic tibiofemoral OA was 1.12% in the active group vs 1.82% in the others (odds ratio (OR) among active group 0.6, 95% confidence interval (CI) 0.3, 1.3). Joint space narrowing occurred in 3.41% of knees in the active group vs 4.04% in the others (OR among active group 0.9 (95% CI 0.5, 1.5)). Results did not differ by alignment status. Conclusions: Physical activity in the highest quartile did not affect the risk of developing OA.
机译：目的：根据膝关节的位置，确定体育锻炼对无膝关节损伤的人膝骨关节炎（OA）发展的影响。设计：我们结合了多中心骨关节炎（MOST）和骨关节炎倡议（OAI）的数据，对患有OA或高OA风险的人进行了研究。受试者有长肢和重复的后前膝关节X光片，并完成了老年人的身体活动调查（PASE）。我们研究了没有放射线照相OA的人，排除了膝关节严重损伤且没有长肢膜的人。我们追踪受试者30个月（MOST）和48个月（OAI）的两个事件结果之一：（1）有症状的胫骨股骨OA（放射照相OA和膝关节疼痛），或（2）胫骨股骨变窄。 “活跃”的人是那些按性别分列最高四分位的人。我们使用逻辑回归分析了年龄，性别，体重指数（BMI），西安大略和麦克马斯特关节炎指数（WOMAC）疼痛评分，凯格伦和劳伦斯（KL）等级（0或1）以及起源研究。我们还分析了肢体未对准和中立的膝盖。结果：合并样本包括2,073名受试者（3,542膝），平均年龄61岁。有症状的胫股骨OA的累积发生率在活动组为1.12％，在其他组为1.82％（活动组的比值比（OR）为0.6，95％的置信区间（CI）为0.3，1.3）。活动组膝关节的关节间隙变窄发生在3.41％，其他组膝关节的关节间隙变窄为4.04％（活动组的OR为0.9（95％CI 0.5，1.5））。结果根据对齐状态没有差异。结论：最高四分位数的体育锻炼不会影响发生OA的风险。

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