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首页> 外文期刊>Osteoarthritis and cartilage >Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction
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Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction

机译：阳离子剂对比增强的计算机X线断层扫描成像与压缩模量和摩擦系数相关

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Objective: The aim of this study is to evaluate whether contrast-enhanced computed tomography (CECT) attenuation, using a cationic contrast agent (CA4+), correlates with the equilibrium compressive modulus (E) and coefficient of friction (μ) of ex vivo bovine articular cartilage. Methods: Correlations between CECT attenuation and E (Group 1, n = 12) and μ (Group 2, n = 10) were determined using 7 mm diameter bovine osteochondral plugs from the stifle joints of six freshly slaughtered, skeletally mature cows. The equilibrium compressive modulus was measured using a four-step, unconfined, compressive stress-relaxation test, and the coefficients of friction were determined from a torsional friction test. Following mechanical testing, samples were immersed in CA4+, imaged using μCT, rinsed, and analyzed for glycosaminoglycan (GAG) content using the 1,9-dimethylmethylene blue (DMMB) assay. Results: The CECT attenuation was positively correlated with the GAG content of bovine cartilage (R2 = 0.87, P 0.0001 for Group 1 and R2 = 0.74, P = 0.001 for Group 2). Strong and significant positive correlations were observed between E and GAG content (R2 = 0.90, P 0.0001) as well as CECT attenuation and E (R2 = 0.90, P 0.0001). The CECT attenuation was negatively correlated with the three coefficients of friction: CECT vs μstatic (R2 = 0.71, P = 0.002), CECT vs μstatic_equilibrium (R2 = 0.79, P 0.001), and CECT vs μkinetic (R2 = 0.69, P = 0.003). Conclusions: CECT with CA4+ is a useful tool for determining the mechanical properties of ex vivo cartilage tissue as the attenuation significantly correlates with the compressive modulus and coefficient of friction.
机译：目的：本研究的目的是评估使用阳离子造影剂（CA4 +）的造影增强计算机体层摄影（CECT）衰减是否与离体牛的平衡压缩模量（E）和摩擦系数（μ）相关关节软骨。方法：使用直径为7 mm的牛骨软骨栓塞从6头刚宰杀的骨骼成熟母牛的窒息关节中确定CECT衰减与E（第1组，n = 12）和μ（第2组，n = 10）之间的相关性。平衡压缩模量使用四步，无限制，压缩应力松弛测试进行测量，摩擦系数由扭转摩擦测试确定。机械测试后，将样品浸入CA4 +中，使用μCT成像，冲洗，并使用1,9-二甲基亚甲基蓝（DMMB）分析糖胺聚糖（GAG）含量。结果：CECT衰减与牛软骨的GAG含量呈正相关（第1组R2 = 0.87，P <0.0001，第2组R2 = 0.74，P = 0.001）。在E和GAG含量（R2 = 0.90，P <0.0001）以及CECT衰减和E（R2 = 0.90，P <0.0001）之间观察到强而显着的正相关。 CECT衰减与三个摩擦系数呈负相关：CECT与静态摩擦（R2 = 0.71，P = 0.002），CECT与静态摩擦（R2 = 0.79，P <0.001）和CECT与运动动力学（R2 = 0.69，P = 0.003）。结论：带有CA4 +的CECT是确定离体软骨组织机械特性的有用工具，因为衰减与压缩模量和摩擦系数显着相关。

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