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The layered structure of the articular surface

机译：关节面的分层结构

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Objective: Articular cartilage is roughly separated into three areas: the tangential, middle, and deep zones. The structure and molecular components of an additional important zone, the most superficial zone (MSZ), which directly faces the joint cavity, have yet to be conclusively elucidated. The purpose of the present study was to use multiple methods to study the MSZ in order to determine its structure. Materials and methods: Knees from 16 pigs (age, 6 months) were used. Full-thickness cartilage specimens were harvested from the femoral groove. The MSZ was observed using light microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM) in combination with histochemical and immunohistochemical methods. Results: The combined findings from the three different observational methods indicate that the MSZ is subdivided into three layers. Among these three layers, collagen subtypes I, II, and III are present in the innermost (third) layer of the MSZ. Beneath the third layer, type II collagen is the predominant type, with small amounts of type III collagen. This layer beneath the third layer is considered to be the tangential layer. Conclusions: Our observations indicate that the MSZ is subdivided into three layers. Further analysis of the molecular components in each layer may improve our understanding of the structure of the articular surface.
机译：目的：关节软骨大致分为三个区域：切向，中间和深部区域。还没有明确阐明直接面对关节腔的另一个重要区域，即最表层区域（MSZ）的结构和分子成分。本研究的目的是使用多种方法研究MSZ，以确定其结构。材料和方法：使用16头猪（6个月大）的膝盖。从股骨沟中收获全厚度的软骨标本。结合组织化学和免疫组织化学方法，使用光学显微镜，透射电子显微镜（TEM）和扫描电子显微镜（SEM）观察了MSZ。结果：来自三种不同观测方法的综合发现表明，MSZ分为三层。在这三层中，胶原蛋白亚型I，II和III存在于MSZ的最内层（第三层）。在第三层下面，II型胶原蛋白是主要类型，少量的III型胶原蛋白。第三层下面的这一层被认为是切线层。结论：我们的观察表明，MSZ分为三层。对每一层中分子成分的进一步分析可以增进我们对关节表面结构的理解。

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