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首页> 外文期刊>Osteoarthritis and cartilage >Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model
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Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model

机译：高分子交联透明质酸对兔膝骨关节炎模型的软骨保护作用

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Objectives: We hypothesized that high-molecular-weight (MW) cross-linked (CL) hyaluronic acid (HA) improves joint lubrication and has an enhanced chondroprotective effect. We examined the histopathological changes and friction coefficients in osteoarthritic knee joints after injecting high-MW CL HA. Design: A bilateral anterior cruciate ligament transection (ACLT) model in 20 Japanese white rabbits was used. From week 5 after transection, low-MW HA (0.8×106Da; HA80) or high-MW CL HA (6×106Da; HA600) was injected weekly into 10 right knee for 3 weeks; normal saline (NS) was injected into the 10 left knee. A sham operation was undertaken to exclude spontaneous osteoarthritis (OA) in five knees. Results were evaluated with macroscopy, histopathology (Kikuchi's score), biomechanical testing, and rheological assessment of the joint fluid viscoelasticity. Statistical analysis was performed using one-way analysis of variance with a 95% confidence interval (CI) (P0.05). Results: The macroscopic findings showed severely damaged cartilage in 30% of the NS group and 20% of the HA80 and HA600 groups and intact cartilage in 100% of the sham group. The histological scores and friction coefficients of the HA600 group were significantly lower than those of the NS group (P=0.007 and P=0.002, respectively). Viscoelasticity measurements of the joint fluid showed no significant differences between the three treatment groups. Conclusion: High-MW CL HA exerts potential chondroprotective effects and produces superior friction coefficients. Our results suggest that HA600 delays the progression of OA effectively and improves joint lubrication significantly.
机译：目的：我们假设，高分子量（MW）交联（CL）透明质酸（HA）可以改善关节润滑并增强软骨保护作用。我们在注射高分子量CL HA后检查了骨关节炎膝关节的组织病理学变化和摩擦系数。设计：在20只日本白兔中使用双侧前交叉韧带横断（ACLT）模型。从横切后的第5周开始，每周向低位10只右膝注射低MW HA（0.8×106Da; HA80）或高MW CL HA（6×106Da; HA600），持续3周。将生理盐水（NS）注入左10个膝盖。进行假手术以排除五个膝盖的自发性骨关节炎（OA）。通过宏观检查，组织病理学（菊池评分），生物力学测试以及关节液粘弹性的流变学评估对结果进行评估。使用单向方差分析以95％的置信区间（CI）进行统计分析（P <0.05）。结果：肉眼可见，NS组中30％的软骨严重受损，HA80和HA600组中20％的软骨严重受损，假手术组中100％的软骨完整受损。 HA600组的组织学评分和摩擦系数显着低于NS组（分别为P = 0.007和P = 0.002）。关节液的粘弹性测量显示三个治疗组之间没有显着差异。结论：高分子量CL HA具有潜在的软骨保护作用，并产生优异的摩擦系数。我们的结果表明，HA600有效地延迟了OA的进程并显着改善了关节润滑。

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