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首页> 外文期刊>Osteoarthritis and cartilage >Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain.
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Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain.

机译：骨关节炎疼痛的单碘乙酸酯模型中pat下脂肪垫的细胞和组织病理学变化。

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OBJECTIVE: The infrapatellar fat pad (IPFP) has been identified as a source of anterior knee pain. Fibrosis and marked inflammatory infiltrate in the IPFP of patients with arthritis of the knee and reduction in pain post knee replacement in patients following resection of the IPFP have been observed. We have investigated changes in the IPFP of rats undergoing the monoiodoacetate (MIA) model of degenerative joint disease, a model that exhibits some histopathological similarities to osteoarthritis (OA). METHODS: Rats were injected intra-articularly with MIA and the development of weight bearing asymmetry was followed for 21 days as compared to vehicle-injected animals. In addition, IPFPs were removed from both ipsilateral and contralateral joints. Both inflammatory infiltrate and histopathological changes were analysed. RESULTS: MIA injection caused marked weight bearing asymmetry. Ipsilateral IPFP wet weights were significantly increased on days 1 and 3 in MIA-treated animals. MIA treatment also resulted in significant increases in IPFP total white blood cells and monocytes on days 1, 3, and 7 and neutrophils on days 1 and 3. This was supported by histopathological findings at early time points which progressed to adipocyte necrosis, IPFP fibrosis, patellar cartilage and subchondral bone necrosis with synovial hyperplasia at later timepoints. CONCLUSIONS: The current study clearly demonstrated that marked inflammatory changes in the IPFP occur during the early stage of the MIA model of OA which may contribute to the pain observed at this early stage. The role of the IPFP in later stages of the model needs to be further explored.
机译：目的：pat下脂肪垫（IPFP）被确定为膝前疼痛的来源。观察到膝关节炎患者的IPFP中有纤维化和明显的炎症浸润，并且在IPFP切除后的患者中，膝关节置换术后疼痛减轻。我们已经研究了变性关节病的单碘乙酸盐（MIA）模型大鼠的IPFP的变化，该模型表现出与骨关节炎（OA）的一些组织病理学相似性。方法：向大鼠关节内注射MIA，与赋形剂注射的动物相比，持续21天追踪负重的不对称性。此外，从同侧和对侧关节中均去除了IPFP。分析了炎性浸润和组织病理学变化。结果：MIA注射引起明显的负重不对称。在经MIA处理的动物中，同侧IPFP湿重在第1天和第3天显着增加。 MIA治疗还导致第1、3和7天的IPFP总白细胞和单核细胞显着增加，第1和3天的中性粒细胞显着增加。这在早期的组织病理学发现中得到了支持，并逐渐发展为脂肪细胞坏死，IPFP纤维化， later骨软骨和软骨下骨坏死伴滑膜增生在以后的时间点。结论：目前的研究清楚地表明，在OA的MIA模型的早期阶段，IPFP中发生了明显的炎症变化，这可能导致了在此早期阶段观察到的疼痛。 IPFP在模型的后期阶段中的作用有待进一步探讨。

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