...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Osteoarthritis and cartilage >Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.
【24h】

Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.

机译：在骨关节炎大鼠模型中，口服鲑鱼降钙素可减少软骨和骨病理，并增加软骨下骨转换。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Traumatic osteoarthritis (OA) is possibly augmented by effects from loss of sex hormones. Salmon calcitonin is shown to reduce OA pathogenesis and bone resorption. We investigated the effects of oral salmon calcitonin treatment and ovariectomy on cartilage and bone pathology in a traumatic OA model. METHODS: Six groups with 10 7-month-old female Sprague Dawley rats each were subjected to bilateral meniscectomy (MNX), ovariectomy (OVX) or Sham surgery and treated for 8 weeks with oral salmon calcitonin (CT) or vehicle (V) in the following way: (1) Sham+V; (2) MNX+V; (3) MNX+CT; (4) OVX+V; (5) MNX/OVX+V; (6) MNX/OVX+CT. Weights were recorded weekly and CTX-II was measured in serum. At termination 56 days post-surgery, the right tibia was analyzed for changes in articular cartilage thickness, extent of cartilage damage and subchondral bone changes in predefined zones, as recommended in the novel OARSI histopathology score. RESULTS: The combined MNX/OVX model produced a significantly reduced cartilage thickness (P=0.033) in the outer zone (Z1) of the tibial plateau and increased calcified cartilage damage (P=0.0004) and serum CTX-II (P=0.003). Addition of OVX to MNX significantly increased the width of matrix damage at the surface (P=0.025) and 50% cartilage depth (P=0.004). Treatment with oral salmon calcitonin counteracted the loss of cartilage thickness (P=0.055), significantly reduced subchondral bone damage score (P=0.019) and reduced the type II collagen degradation (P=0.009). CONCLUSIONS: Addition of ovariectomy augmented site-specific traumatic OA pathology, which was reduced by oral salmon calcitonin treatment. Treatments for OA might ideally affect both bone and cartilage.
机译：目的：性激素损失可能会增加创伤性骨关节炎（OA）。鲑鱼降钙素显示可减少OA发病机理和骨吸收。我们调查了创伤性OA模型中口服鲑鱼降钙素的治疗和卵巢切除术对软骨和骨病理学的影响。方法：六组，每组10只7个月大的Sprague Dawley雌性大鼠，分别接受双侧半月板切除（MNX），卵巢切除（OVX）或Sham手术，并在口腔内用鲑鱼降钙素（CT）或媒介物（V）治疗8周。 （1）Sham + V; （2）MNX + V; （3）MNX + CT; （4）OVX + V; （5）MNX / OVX + V; （6）MNX / OVX + CT。每周记录体重，并在血清中测量CTX-II。在手术后第56天终止时，按照新的OARSI组织病理学评分中的建议，分析了右胫骨的关节软骨厚度，软骨损伤程度和软骨下骨变化的预定义区域。结果：MNX / OVX组合模型在胫骨平台外区（Z1）的软骨厚度（P = 0.033）明显降低，钙化软骨损伤（P = 0.0004）和血清CTX-II（P = 0.003）升高。 。在MNX上添加OVX显着增加了表面基质破坏的宽度（P = 0.025）和50％的软骨深度（P = 0.004）。口服鲑鱼降钙素治疗可抵消软骨厚度的损失（P = 0.055），显着降低软骨下骨损伤评分（P = 0.019）并减少II型胶原降解（P = 0.009）。结论：卵巢切除术增加了特定部位的创伤性OA病理，口服鲑鱼降钙素治疗可以减轻这种情况。 OA的治疗可能理想地影响骨骼和软骨。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号