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T2* mapping of hip joint cartilage in various histological grades of degeneration

机译：不同组织学变性程度的髋关节软骨的T2 *定位

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Objective: To evaluate T2* values in various histological severities of osteoarthritis (OA). Method: Magnetic resonance imaging (MRI) and T2* mapping including a three-dimensional (3D) double-echo steady-state (DESS) sequence for morphological cartilage assessment and a 3D multiecho data image combination (MEDIC) sequence for T2* mapping were conducted in 21 human femoral head specimens with varying severities of OA. Subsequently, histological assessment was undertaken in all specimens to correlate the observations of T2* mapping with histological analyses. According to the Mankin score, four grades of histological changes were determined: grade 0 (Mankin scores of 0-4), grade I (scores of 5-8), grade II (scores of 9-10), and grade III (scores of 11-14). For reliability assessment, cartilage T2* measurements were repeated after 4 weeks in 10 randomly selected femoral head specimens. Results: T2* values decreased significantly with increasing cartilage degeneration (total . P-values <0.001) ranging from 36.3 ± 4.3 ms in grade 0 regions to 22.8 ± 4.3 ms in regions with grade III changes. Pearson correlation analysis proved a fair correlation between T2* values and Mankin score (correlation coefficient = -0.362) that was statistically significant (. P-value <0.001). Intra-class correlation (ICC) analysis demonstrated high intra-observer reproducibility for the T2* measurement (ICC: 0.949, . P < 0.001). Conclusions: Given the advantages of the T2* mapping technique with no need for contrast medium, high image resolution and ability to perform 3D biochemically sensitive imaging, T2* mapping may be a strong addition to the currently evolving era of cartilage biochemical imaging.
机译：目的：评估各种组织学严重程度骨关节炎（OA）中的T2 *值。方法：磁共振成像（MRI）和T2 *映射包括用于形态软骨评估的三维（3D）双回波稳态（DESS）序列和用于T2 *映射的3D多回波数据图像组合（MEDIC）序列在21例不同严重程度的OA的人股骨头样本中进行。随后，对所有标本进行组织学评估，以将T2 *作图的观察结果与组织学分析相关联。根据Mankin评分，确定了四个组织学变化等级：0级（Mankin评分为0-4），I级（评分为5-8），II级（评分为9-10）和III级（评分） 11-14）。为了进行可靠性评估，在10个随机选择的股骨头标本中，在4周后重复进行软骨T2 *测量。结果：T2 *值随着软骨变性的增加而显着降低（总P值<0.001），范围从0级36.3±4.3 ms到III级变化22.8±4.3 ms。皮尔逊相关分析证明T2 *值与Mankin评分（相关系数= -0.362）之间具有合理的相关性，具有统计学意义（。P值<0.001）。类内相关性（ICC）分析表明，观察者对T2 *的测量具有较高的可重复性（ICC：0.949，。P <0.001）。结论：鉴于T2 *映射技术的优势，不需要造影剂，高图像分辨率和执行3D生化敏感成像的能力，T2 *映射可能是当前软骨生化成像时代的有力补充。

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