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首页> 外文期刊>Osteoarthritis and cartilage >Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans
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Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans

机译：epi骨软骨管的血管横切会导致小腿股骨-关节的骨软骨病和骨软骨病剥离;解剖型少年骨软骨炎的潜在模型

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Objective: To transect blood vessels within epiphyseal cartilage canals and observe whether this resulted in ischaemic chondronecrosis, an associated focal delay in enchondral ossification [osteochondrosis (OC)] and pathological cartilage fracture [. osteochondrosis dissecans (OCD)] in the distal femur of foals, with potential translational value to the pathogenesis of juvenile osteochondritis dissecans (JOCD) in children. Method: Ten Norwegian Fjord Pony foals were operated at the age of 13-15 days. Two vessels supplying the epiphyseal growth cartilage of the lateral trochlear ridge of the left distal femur were transected in each foal. Follow-up examination was carried out from 1 to 49 days post-operatively and included plain radiography, macroscopic and histological examination. Results: Transection of blood vessels within epiphyseal cartilage canals resulted in necrosis of vessels and chondrocytes, i.e., ischaemic chondronecrosis, in foals. Areas of ischaemic chondronecrosis were associated with a focal delay in enchondral ossification (OC) in foals examined 21 days or more after transection, and pathological cartilage fracture (OCD) in one foal examined 42 days after transection. Conclusion: The ischaemic hypothesis for the pathogenesis of OC has been reproduced experimentally in foals. There are several similarities between OCD in animals and JOCD in children. It should be investigated whether JOCD also occurs due to a focal failure in the cartilage canal blood supply, followed by ischaemic chondronecrosis.
机译：目的：横断epi骨软骨管内的血管，并观察其是否导致缺血性软骨坏死，与之相关的骨软骨化[骨软骨病（OC）]局灶性延迟和病理性软骨骨折[。小马驹股骨远端的解剖性骨软骨病（OCD），对儿童青少年剥离性骨软骨炎（JOCD）的发病机制具有潜在的翻译价值。方法：十只挪威峡湾小马小马驹在13-15天的年龄进行了手术。在每只小马驹中切断两条供应左股骨远端滑车脊骨the骨软骨的血管。术后1至49天进行随访检查，包括X线平片，肉眼检查和组织学检查。结果：epi骨软骨内血管的横穿导致小马的血管和软骨细胞坏死，即缺血性软骨坏死。在横断后21天或更长时间检查的小马驹中，局部缺血性软骨坏死区域与局灶性骨软骨骨化（OC）延迟有关，横断后42天检查的小马驹的病理性软骨骨折（OCD）与局灶性延迟有关。结论：OC发病机理的缺血假说已在小马驹上得到了实验性的再现。动物的强迫症和儿童的强迫症之间有许多相似之处。应该研究是否由于软骨管血液供应局灶性衰竭继发缺血性软骨坏死而发生JOCD。

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