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首页> 外文期刊>Osteoarthritis and cartilage >Electroarthrography: A novel method to assess articular cartilage and diagnose osteoarthritis by non-invasive measurement of load-induced electrical potentials at the surface of the knee
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Electroarthrography: A novel method to assess articular cartilage and diagnose osteoarthritis by non-invasive measurement of load-induced electrical potentials at the surface of the knee

机译：电描记术：一种通过无创测量膝盖表面负荷诱发电位的方法来评估关节软骨和诊断骨关节炎的新方法

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Objective: A new technique called electroarthrography (EAG) measures electrical potentials on the surface of the knee during joint loading. The objective of this study was to evaluate the effectiveness of EAG to assess joint cartilage degeneration. Design: EAG recordings were performed on 20 asymptomatic subjects (Control group) and on 20 patients with bilateral knee osteoarthritis (OA) who had had a unilateral total knee replacement (TKR), both the TKR knee and the remaining knee were analyzed. EAG signals were recorded at eight electrode sites over one knee as the subjects shifted their weight from one leg to the other to achieve joint loading. The EAG signals were filtered, baseline-corrected and time-averaged. Results: EAG repeatability was assessed with a test-retest protocol which showed statistically significant high intraclass correlation coefficients (ICC) for four electrode sites near the joint line. These sites also showed the highest mean EAG values. The mean EAG potentials of the Control group were significantly higher compared with the OA group for three sites overlying the joint line. The potentials overlying the TKR were statistically nul. In the Control group, no statistically significant correlation was found between the EAG amplitude and age, weight, height or body mass index (BMI); no statistical difference was found in mean EAG potentials between women and men. Conclusions: This study indicates that EAG signals arise from the streaming potentials in compressed articular cartilage which are known sensitive indicators of joint cartilage health. EAG is a promising new technique for the non-invasive assessment of cartilage degeneration and arthritis.
机译：目的：一种称为关节电描记术（EAG）的新技术可测量关节负荷过程中膝盖表面的电位。这项研究的目的是评估EAG评估关节软骨变性的有效性。设计：对20例无症状的受试者（对照组）和20例单侧全膝关节置换（TKR）的双侧膝骨关节炎（OA）患者进行了EAG记录，同时分析了TKR膝和剩余的膝。当受试者将体重从一只腿转移到另一只腿上以达到关节负荷时，在一个膝盖上的八个电极部位记录了EAG信号。对EAG信号进行滤波，基线校正和时间平均。结果：EAG重复性用重新测试协议进行了评估，该协议显示出在关节线附近的四个电极部位，统计学上显着的高组内相关系数（ICC）。这些位点还显示出最高的平均EAG值。与OA组相比，对照组的平均EAG电位明显高于OA组。覆盖TKR的潜力在统计上为零。在对照组中，EAG振幅与年龄，体重，身高或体重指数（BMI）之间未发现统计学上的显着相关性。男女平均EAG潜能没有统计学差异。结论：这项研究表明，EAG信号来自于压缩的关节软骨中的流动电位，这是关节软骨健康的已知敏感指标。 EAG是用于软骨变性和关节炎的非侵入性评估的有前途的新技术。

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